Role and mechanism of autophagy‐regulating factors in tumorigenesis and drug resistance
RM Usman, F Razzaq, A Akbar… - Asia‐Pacific Journal …, 2021 - Wiley Online Library
A hallmark feature of tumorigenesis is uncontrolled cell division. Autophagy is regulated by
more than 30 genes and it is one of several mechanisms by which cells maintain …
more than 30 genes and it is one of several mechanisms by which cells maintain …
Diversity and inter-connections in the CXCR4 chemokine receptor/ligand family: molecular perspectives
L Pawig, C Klasen, C Weber, J Bernhagen… - Frontiers in …, 2015 - frontiersin.org
CXCR4 and its ligand CXCL12 mediate the homing of progenitor cells in the bone marrow
and their recruitment to sites of injury, as well as affect processes such as cell arrest …
and their recruitment to sites of injury, as well as affect processes such as cell arrest …
Colon cancer cells escape 5FU chemotherapy-induced cell death by entering stemness and quiescence associated with the c-Yes/YAP axis
Y Touil, W Igoudjil, M Corvaisier, AF Dessein… - Clinical cancer …, 2014 - AACR
Purpose: Metastasis and drug resistance are the major limitations in the survival and
management of patients with cancer. This study aimed to identify the mechanisms …
management of patients with cancer. This study aimed to identify the mechanisms …
CXCR4 antagonist AMD3100 (plerixafor): From an impurity to a therapeutic agent
J Wang, BA Tannous, MC Poznansky, H Chen - Pharmacological research, 2020 - Elsevier
Abstract AMD3100 (plerixafor), a CXCR4 antagonist, has opened a variety of avenues for
potential therapeutic approaches in different refractory diseases. The CXCL12/CXCR4 axis …
potential therapeutic approaches in different refractory diseases. The CXCL12/CXCR4 axis …
Macrophage migration inhibitory factor–CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors
S Lourenco, VH Teixeira, T Kalber, RJ Jose… - The Journal of …, 2015 - journals.aai.org
Mesenchymal stromal cells (MSCs) are inherently tumor homing and can be isolated,
expanded, and transduced, making them viable candidates for cell therapy. This tumor …
expanded, and transduced, making them viable candidates for cell therapy. This tumor …
ZFPM2-AS1, a novel lncRNA, attenuates the p53 pathway and promotes gastric carcinogenesis by stabilizing MIF
F Kong, X Deng, X Kong, Y Du, L Li, H Zhu, Y Wang… - Oncogene, 2018 - nature.com
Long non-coding RNAs (lncRNAs) are implicated to be involved in the pathogenesis of
many cancers. Herein we report on our discovery of a novel lncRNA, ZFPM2 antisense RNA …
many cancers. Herein we report on our discovery of a novel lncRNA, ZFPM2 antisense RNA …
MIF promotes B cell chemotaxis through the receptors CXCR4 and CD74 and ZAP-70 signaling
C Klasen, K Ohl, M Sternkopf, I Shachar… - The Journal of …, 2014 - journals.aai.org
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine with chemokine-
like functions that plays a pivotal role in the pathogenesis of inflammatory diseases by …
like functions that plays a pivotal role in the pathogenesis of inflammatory diseases by …
Polyfunctionality of the CXCR4/CXCL12 axis in health and disease: Implications for therapeutic interventions in cancer and immune‐mediated diseases
C Britton, MC Poznansky, P Reeves - The FASEB Journal, 2021 - Wiley Online Library
Historically the chemokine receptor CXCR4 and its canonical ligand CXCL12 are
associated with the bone marrow niche and hematopoiesis. However, CXCL12 exhibits …
associated with the bone marrow niche and hematopoiesis. However, CXCL12 exhibits …
Designed CXCR4 mimic acts as a soluble chemokine receptor that blocks atherogenic inflammation by agonist-specific targeting
C Kontos, O El Bounkari, C Krammer, D Sinitski… - Nature …, 2020 - nature.com
Targeting a specific chemokine/receptor axis in atherosclerosis remains challenging.
Soluble receptor-based strategies are not established for chemokine receptors due to their …
Soluble receptor-based strategies are not established for chemokine receptors due to their …
Arrest functions of the MIF ligand/receptor axes in atherogenesis
S Tillmann, J Bernhagen, H Noels - Frontiers in immunology, 2013 - frontiersin.org
Macrophage migration inhibitory factor (MIF) has been defined as an important chemokine-
like function (CLF) chemokine with an essential role in monocyte recruitment and arrest …
like function (CLF) chemokine with an essential role in monocyte recruitment and arrest …