Simple Summary Cell migration is an essential process from embryogenesis to cell death.
This is tightly regulated by numerous proteins that help in proper functioning of the cell. In …

At first glance, the platelet is a simple cell. However, its small size hides an extremely well
conserved structure that is vital for its function in both hemostasis and vascular integrity and …

Every day, megakaryocytes produce billions of platelets that circulate for several days and
eventually are cleared by the liver. The exact removal mechanism, however, remains …

Coordinated polymerization of actin filaments provides force for cell migration,
morphogenesis and endocytosis. Capping protein (CP) is a central regulator of actin …

Background Platelets circulate in the blood of healthy individuals for approximately 7–10
days regulated by finely balanced processes of production and destruction. As platelets are …

Platelet ageing is an area of research which has gained much interest in recent years.
Newly formed platelets, often referred to as reticulated platelets, young platelets or immature …

Hyperreactive platelets are commonly observed in diabetic patients indicating a potential
link between glucose homeostasis and platelet reactivity. This raises the possibility that …

We have established considerable expertise in studying the role of platelets in cancer
biology. From this expertise, we were keen to recognize the numerous venous-, arterial …

The process of platelet production has so far been understood to be a 2-stage process:
megakaryocyte maturation from hematopoietic stem cells followed by proplatelet formation …

Oxidative stress and iron accumulation-induced ferroptosis occurs in injured vascular cells
and can promote thrombogenesis. Transferrin receptor 1 (encoded by the TFRC gene) is an …