The insulin-like growth factor system and colorectal cancer
Insulin-like growth factors (IGFs) are peptides which exert mitogenic, endocrine and cytokine
activities. Together with their receptors, binding proteins and associated molecules, they …
activities. Together with their receptors, binding proteins and associated molecules, they …
Ferrocene-modified phospholipid: an innovative precursor for redox-triggered drug delivery vesicles selective to cancer cells
T Noyhouzer, C L'Homme, I Beaulieu, S Mazurkiewicz… - Langmuir, 2016 - ACS Publications
Controlled payload release is one of the key elements in the creation of a reliable drug
delivery system. We report the discovery of a drug delivery vessel able to transport …
delivery system. We report the discovery of a drug delivery vessel able to transport …
New approach for treatment of primary liver tumors: the role of quercetin
abstract Hepatocellular carcinoma (HCC) is the most common primary liver tumor (PLT), with
cholangiocarcinoma (CC) being the second most frequent. Glucose transporter 1 (GLUT-1) …
cholangiocarcinoma (CC) being the second most frequent. Glucose transporter 1 (GLUT-1) …
99mTc-amitrole as a novel selective imaging probe for solid tumor: in silico and preclinical pharmacological study
Lactoperoxidase (LPO) inhibitors are very selective for solid tumor due to their high binding
affinity to the LPO enzyme. A computational study was used to select top-ranked LPO …
affinity to the LPO enzyme. A computational study was used to select top-ranked LPO …
Synthesis, radiolabeling and biological distribution of a new dioxime derivative as a potential tumor imaging agent
MA Motaleb, AA Selim, M El-Tawoosy… - … of Radioanalytical and …, 2017 - Springer
A novel dioxime derivative (2 E, 2′ E, 3 E, 3′ E)-3, 3′-(pyrimidine-4, 5-diylbis
(azanylylidene)) bis (butan-2-one) dioxime was synthesized with a yield of 65%. IR …
(azanylylidene)) bis (butan-2-one) dioxime was synthesized with a yield of 65%. IR …
Selective cytotoxicity and cell death induced by human amniotic membrane in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) has a worldwide high incidence and mortality. For this
reason, it is essential to invest in new therapies for this type of cancer. Our team already …
reason, it is essential to invest in new therapies for this type of cancer. Our team already …
Cytotoxicity of ascorbic acid in a human colorectal adenocarcinoma cell line (WiDr): in vitro and in vivo studies
Vitamin C, available in its reduced form (ascorbic acid; AA) and in its oxidized form
(dehydroascorbic acid; DHA), may act in physiological conditions as an antioxidant or pro …
(dehydroascorbic acid; DHA), may act in physiological conditions as an antioxidant or pro …
Biodistribution of 99mTc‐sunitinib as a potential radiotracer for tumor hypoxia imaging
TM Sakr, DM El‐Safoury, GAS Awad… - Journal of Labelled …, 2013 - Wiley Online Library
Tyrosine kinases are groups of enzymes, which are over‐expressed in solid tumor cells,
representing good targets for different drugs such as sunitinib (N‐[2‐(diethylamino) ethyl]‐5 …
representing good targets for different drugs such as sunitinib (N‐[2‐(diethylamino) ethyl]‐5 …
Endometrial cancer spheres show cancer stem cells phenotype and preference for oxidative metabolism
MJ Carvalho, M Laranjo, AM Abrantes… - Pathology & Oncology …, 2019 - Springer
This study aimed to characterize endometrial cancer regarding cancer stem cells (CSC)
markers, regulatory and differentiation pathways, tumorigenicity and glucose metabolism …
markers, regulatory and differentiation pathways, tumorigenicity and glucose metabolism …
2-Bromo-5-hydroxyphenylporphyrins for photodynamic therapy: Photosensitization efficiency, subcellular localization and in vivo studies
BACKGROUND: Photodynamic therapy (PDT) is a therapeutic modality capable of inducing
cell death by oxidative stress through activation of a sensitizer by light. Aryl-porphyrin with …
cell death by oxidative stress through activation of a sensitizer by light. Aryl-porphyrin with …