Lipid metabolism and Alzheimer's disease: clinical evidence, mechanistic link and therapeutic promise

F Yin - The FEBS journal, 2023 - Wiley Online Library
Alzheimer's disease (AD) is an age‐associated neurodegenerative disorder with
multifactorial etiology, intersecting genetic and environmental risk factors, and a lack of …

Alzheimer's pathogenic mechanisms and underlying sex difference

D Zhu, A Montagne, Z Zhao - Cellular and Molecular Life Sciences, 2021 - Springer
AD is a neurodegenerative disease, and its frequency is often reported to be higher for
women than men: almost two-thirds of patients with AD are women. One prevailing view is …

Brain clocks capture diversity and disparities in aging and dementia across geographically diverse populations

S Moguilner, S Baez, H Hernandez, J Migeot… - Nature medicine, 2024 - nature.com
Brain clocks, which quantify discrepancies between brain age and chronological age, hold
promise for understanding brain health and disease. However, the impact of diversity …

[HTML][HTML] Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice

V Ilievski, PK Zuchowska, SJ Green, PT Toth… - PloS one, 2018 - journals.plos.org
Background The results from cross sectional and longitudinal studies show that periodontitis
is closely associated with cognitive impairment (CI) and Alzhemer's Disease (AD). Further …

Menopause impacts human brain structure, connectivity, energy metabolism, and amyloid-beta deposition

L Mosconi, V Berti, J Dyke, E Schelbaum, S Jett… - Scientific reports, 2021 - nature.com
All women undergo the menopause transition (MT), a neuro-endocrinological process that
impacts aging trajectories of multiple organ systems including brain. The MT occurs over …

Sex differences in the association of global amyloid and regional tau deposition measured by positron emission tomography in clinically normal older adults

RF Buckley, EC Mormino, JS Rabin, TJ Hohman… - JAMA …, 2019 - jamanetwork.com
Importance Mounting evidence suggests that sex differences exist in the pathologic
trajectory of Alzheimer disease. Previous literature shows elevated levels of cerebrospinal …

Endogenous and exogenous estrogen exposures: how women's reproductive health can drive brain aging and inform Alzheimer's prevention

S Jett, N Malviya, E Schelbaum, G Jang… - Frontiers in Aging …, 2022 - frontiersin.org
After advanced age, female sex is the major risk factor for late-onset Alzheimer's disease
(AD), the most common cause of dementia affecting over 24 million people worldwide. The …

The peri-menopause in a woman's life: a systemic inflammatory phase that enables later neurodegenerative disease

M McCarthy, AP Raval - Journal of neuroinflammation, 2020 - Springer
The peri-menopause or menopausal transition—the time period that surrounds the final
years of a woman's reproductive life—is associated with profound reproductive and …

Sex steroids and the female brain across the lifespan: insights into risk of depression and Alzheimer's disease

C Barth, A Crestol, AMG de Lange… - The Lancet Diabetes & …, 2023 - thelancet.com
Despite widespread sex differences in prevalence and presentation of numerous illnesses
affecting the human brain, there has been little focus on the effect of endocrine ageing. Most …

Female sex and Alzheimer's risk: the menopause connection

O Scheyer, A Rahman, H Hristov, C Berkowitz… - The journal of …, 2018 - Springer
Along with advanced age and apolipoprotein E (APOE)-4 genotype, female sex is a major
risk factor for developing late-onset Alzheimer's disease (AD). Considering that AD …