An update on microcrystalline cellulose in direct compression: Functionality, critical material attributes, and co-processed excipients

H Zhao, L Zhao, X Lin, L Shen - Carbohydrate Polymers, 2022 - Elsevier
Microcrystalline cellulose (MCC) is one of the most popular cellulose derivatives in the
pharmaceutical industry. Thanks to its outstanding tabletability, MCC is generally included in …

Non‐destructive characterization of pulse flours—A review

C Sivakumar, CRJ Findlay… - … Reviews in Food …, 2023 - Wiley Online Library
The consumption of plant‐based proteins sourced from pulses is sustainable from the
perspective of agriculture, environment, food security, and nutrition. Increased incorporation …

[HTML][HTML] The use of X-ray microtomography to investigate the microstructure of pharmaceutical tablets: Potentials and comparison to common physical methods

AK Schomberg, A Diener, I Wünsch, JH Finke… - International Journal of …, 2021 - Elsevier
Within this study, tablets microstructure was investigated by X-ray microtomgraphy. The aim
was to gain information about their microstructure, and thus, derive deeper interpretation of …

Characterization of pharmaceutical tablets by X-ray tomography

J Vijayakumar, NM Goudarzi, G Eeckhaut… - Pharmaceuticals, 2023 - mdpi.com
Solid dosage forms such as tablets are extensively used in drug administration for their
simplicity and large-scale manufacturing capabilities. High-resolution X-ray tomography is …

[HTML][HTML] 3D characterisation of dry powder inhaler formulations: Developing X-ray micro computed tomography approaches

P Gajjar, ID Styliari, TTH Nguyen, J Carr, X Chen… - European Journal of …, 2020 - Elsevier
Carrier-based dry powder inhaler (DPI) formulations need to be accurately characterised for
their particle size distributions, surface roughnesses, fines contents and flow properties …

In-depth understanding of granule compression behavior under variable raw material and processing conditions

T Casian, S Iurian, A Gâvan, A Porfire, AL Pop… - Pharmaceutics, 2022 - mdpi.com
Tablet manufacturing involves the processing of raw materials through several unit
operations. Thus, the mitigation of input-induced variability should also consider the …

[HTML][HTML] A micro-XRT image analysis and machine learning methodology for the characterisation of multi-particulate capsule formulations

FJS Doerr, AJ Florence - International journal of pharmaceutics: X, 2020 - Elsevier
The application of X-ray microtomography for quantitative structural analysis of
pharmaceutical multi-particulate systems was demonstrated for commercial capsules, each …

Co-processed excipients for dispersible tablets—part 2: patient acceptability

K Dziemidowicz, FL Lopez, BJ Bowles, AJ Edwards… - AAPS …, 2018 - Springer
Palatability and patient acceptability are critical attributes of dispersible tablet formulation.
Co-processed excipients could provide improved organoleptic profile due to rational choice …

Study of drug particle distributions within mini-tablets using synchrotron X-ray microtomography and superpixel image clustering

L Wagner-Hattler, G Québatte, J Keiser… - International journal of …, 2020 - Elsevier
Uniform drug distribution within fast disintegrating tablets is a key quality measure to ensure
a reliable, steady, and targeted release of the contained active pharmaceutical ingredients …

Advances in Structure Pharmaceutics from Discovery to Evaluation and Design

H Xu, L Wu, Y Xue, T Yang, T Xiong… - Molecular …, 2023 - ACS Publications
Drug delivery systems (DDSs) play an important role in delivering active pharmaceutical
ingredients (APIs) to targeted sites with a predesigned release pattern. The chemical and …