Organoids are simple tissue-engineered cell-based in vitro models that recapitulate many
aspects of the complex structure and function of the corresponding in vivo tissue. They can …

Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …

In the past decade, the term organoid has moved from obscurity to common use to describe
a 3D in vitro cellular model of a tissue that recapitulates structural and functional elements of …

Non-alcoholic fatty liver disease (NAFLD) is reaching epidemic proportions, with a global
prevalence of 25% in the adult population. Non-alcoholic steatohepatitis (NASH), which can …

BACKGROUND A patient-derived organoid (PDO) platform may serve as a promising tool
for translational cancer research. In this study, we evaluated PDO's ability to predict clinical …

Müllerian ducts are paired tubular structures that give rise to most of the female reproductive
organs. Any abnormalities in the development and differentiation of these ducts lead to …

The liver is known as an organ with high proliferation potential. Clarifying the cellular origin
and deepening the understanding of liver regeneration mechanisms will help provide new …

The metabolic, digestive and homeostatic roles of the liver are dependent on proper
crosstalk and organization of hepatic cell lineages. These hepatic cell lineages are derived …

Digestive system diseases arise primarily through the interplay of genetic and environmental
influences; there is an urgent need in elucidating the pathogenic mechanisms of these …