Complex regulation of the immune response is necessary to support effective defense of an
organism against hostile invaders and to maintain tolerance to harmless microorganisms …

The liver is the major target organ of continued alcohol consumption at risk and resulting
alcoholic liver disease (ALD) is the most common liver disease worldwide. The underlying …

Ferroptosis is a form of regulated cell necrosis, as a consequence of Fe (II)-dependent lipid
peroxidation. Although ferroptosis has been linked to cancer cell death, neurodegeneration …

Plasmodium falciparum gametocytes, the sexual stage responsible for malaria parasite
transmission from humans to mosquitoes, are key targets for malaria elimination. Immature …

Iron-restricted human anemias are associated with the acquisition of marrow resistance to
the hematopoietic cytokine erythropoietin (Epo). Regulation of Epo responsiveness by iron …

Metabolic programs contribute to hematopoietic stem and progenitor cell (HSPC) fate, but it
is not known whether the metabolic regulation of protein synthesis controls HSPC …

The metabolic changes controlling the stepwise differentiation of hematopoietic stem and
progenitor cells (HSPCs) to mature erythrocytes are poorly understood. Here, we show that …

Anemia is characteristic of myelodysplastic syndromes (MDS). The mechanisms of anemia
in MDS are unclear. Using a mouse genetic approach, here we show that dual deficiency of …

Self-inflicted DNA strand breaks are canonically linked with cell death pathways and the
establishment of genetic diversity in immune and germline cells. Moreover, this form of DNA …

Selenium (Se) is incorporated as the 21st amino acid selenocysteine (Sec) into the growing
polypeptide chain of proteins involved in redox gatekeeper functions. Erythropoiesis …