In contrast to the major families of small molecules and antibodies, cyclic peptides, as a
family of synthesizable macromolecules, have distinct biochemical and therapeutic …

In this review, we discuss all sulfur-containing FDA-approved drugs and their structures. The
second section of the review is dedicated to structural analysis and is divided into 14 …

The substitution of primary or secondary alcohols with nucleophiles mediated by a redox
combination of a trialkylor triarylphosphine and a dialkyl azodicarboxylate is popularly …

Romidepsin (Istodax), a selective inhibitor of histone deacetylases (HDACs), was approved
for the treatment of cutaneous T-cell lymphoma in November 2009 by the US Food and Drug …

Covering: up to 2014 In this review we investigate the use of complex ester fragment
couplings within natural product total synthesis campaigns. We first outline the different …

Ever since the first isolation of Exaltolide 1 (Figure 1) in 1927 by Kerschbaum, 1 interest in
macrocyclic lactones, defined as lactones with more than 8 atoms in the ring, has been …

Peptides are important biomolecules which facilitate the understanding of complex
biological processes, which in turn could be serendipitous biological targets for future drugs …

Violet-pigmented bacteria, which have been described since the end of the 19th century, are
occasionally the causative agent of septicemia and sometimes cause fatal infection in …

Histones are small basic proteins that, by complexing wtih DNA, form the nucleosome core.
Repetitive units of this nucleosome led to the chromatin in which all the human genome is …

Histone Deacetylase (HDAC) inhibitors are a relatively new class of anti-cancer agents that
play important roles in epigenetic or non-epigenetic regulation, inducing death, apoptosis …