Advances in the synthesis of three typical tetraterpenoids including β-carotene, lycopene and astaxanthin

Y Jing, Y Wang, D Zhou, J Wang, J Li, J Sun… - Biotechnology …, 2022 - Elsevier
Carotenoids are natural pigments that widely exist in nature. Due to their excellent
antioxidant, anticancer and anti-inflammatory properties, carotenoids are commonly used in …

Metabolic engineering for sustainability and health

GB Kim, SY Choi, IJ Cho, DH Ahn, SY Lee - Trends in Biotechnology, 2023 - cell.com
Bio-based production of chemicals and materials has attracted much attention due to the
urgent need to establish sustainability and enhance human health. Metabolic engineering …

Enhanced CO 2 capture for photosynthetic lycopene production in engineered Rhodopseudomonas palustris, a purple nonsulfur bacterium

M Li, Q Xia, S Lv, J Tong, Z Wang, Q Nie, J Yang - Green chemistry, 2022 - pubs.rsc.org
Lycopene has been widely applied in the fields of food additives, drugs and cosmetics due
to its anti-oxidative, anti-cancer, and anti-inflammatory activities. The traditional plant …

Engineering peroxisomal biosynthetic pathways for maximization of triterpene production in Yarrowia lipolytica

Y Ma, Y Shang… - Proceedings of the …, 2024 - National Acad Sciences
Constructing efficient cell factories for product synthesis is frequently hampered by
competing pathways and/or insufficient precursor supply. This is particularly evident in the …

Generative artificial intelligence GPT-4 accelerates knowledge mining and machine learning for synthetic biology

Z Xiao, W Li, H Moon, GW Roell, Y Chen… - ACS synthetic …, 2023 - ACS Publications
Knowledge mining from synthetic biology journal articles for machine learning (ML)
applications is a labor-intensive process. The development of natural language processing …

Metabolic Engineering of Yarrowia lipolytica for Terpenoid Production: Tools and Strategies

TL Zhang, HW Yu, LD Ye - ACS Synthetic Biology, 2023 - ACS Publications
Terpenoids are a diverse group of compounds with isoprene units as basic building blocks.
They are widely used in the food, feed, pharmaceutical, and cosmetic industries due to their …

An unexpected hydratase synthesizes the green light-absorbing pigment fucoxanthin

T Cao, Y Bai, P Buschbeck, Q Tan, MB Cantrell… - The Plant …, 2023 - academic.oup.com
The ketocarotenoid fucoxanthin and its derivatives can absorb blue–green light enriched in
marine environments. Fucoxanthin is widely adopted by phytoplankton species as a main …

Engineering a universal and efficient platform for terpenoid synthesis in yeast

Y Ma, Y Zu, S Huang… - Proceedings of the …, 2023 - National Acad Sciences
Engineering microbes for the production of valuable natural products is often hindered by
the regulation of native competing metabolic networks in host. This is particularly evident in …

Metabolic Engineering of Yarrowia lipolytica for Zeaxanthin Production

G Zhang, J Chen, Y Wang, Z Liu… - Journal of Agricultural and …, 2023 - ACS Publications
Zeaxanthin is a carotenoid, a dihydroxy derivative of β-carotene. Zeaxanthin has antioxidant,
anti-inflammatory, anticancer, and neuroprotective properties. In this study, Yarrowia …

Advances in metabolic engineering paving the way for the efficient biosynthesis of terpenes in yeasts

W Li, L Cui, J Mai, TQ Shi, L Lin, ZG Zhang… - Journal of Agricultural …, 2022 - ACS Publications
Terpenes are a large class of secondary metabolites with diverse structures and functions
that are commonly used as valuable raw materials in food, cosmetics, and medicine. With …