Simple Summary Central America is a region that possesses distinct ecological and
socioeconomic characteristics, making it increasingly vulnerable to vector-borne diseases …

Simple Summary Mosquitoes are the carrier of pathogens that cause common human
diseases such as malaria, Dengue, Chikungunya, yellow fever, Zika, and West Nile. The use …

Mosquito-borne diseases having the greatest impact on human health are typically
prevalent in the tropical belt of the world. However, these diseases are conquering …

Flaviviruses are known to cause a variety of diseases in humans in different parts of the
world. There are very limited numbers of antivirals to combat flavivirus infection, and …

Dengue virus (DENV), which can lead to fatal hemorrhagic fever, affects 390 million people
worldwide. The closely related Zika virus (ZIKV) causes microcephaly in newborns and …

Background Chikungunya virus infection can lead to long-term debilitating symptoms. A
precursor phase 3 clinical study showed high seroprotection (defined as a 50% plaque …

The human population has doubled in the last 50 years from about 3.7 billion to
approximately 7.8 billion. With this rapid expansion, more people live in close contact with …

Background Yellow fever (YF) is a severe, infectious, but non-communicable arboviral
hemorrhagic disease. In the last decades, yellow fever virus (YFV) infections have been …

A major outbreak of yellow fever (YF) occurred in Brazil during 2016–2018. Epizootics in
New World nonhuman primates are sentinel events for YF virus circulation. However, genus …

Zoonotic viruses circulate in the natural reservoir and sporadically spill over into human
populations, resulting in endemics or pandemics. We previously found that the Chaoyang …