Tissue homeostasis is regulated by apoptosis, the cell-suicide programme that is executed
by proteases called caspases. The Bcl2 family of intracellular proteins is the central …

In order to eliminate cells that are redundant, damaged, or infected, metazoan organisms
have evolved the cell suicide mechanism termed apoptosis (Kerr et al. 1972). This genetic …

Activation of the caspases that initiate apoptosis typically requires cognate scaffold proteins,
including CED-4 in Caenorhabditis elegans, Apaf-1 in mammals and Dark in Drosophila …

Apoptosis, an evolutionarily conserved programme of cellular self-destruction, is essential
for the development and survival of most multicellular animals. It is required to ensure …

Genetic analyses in Caenorhabditis elegans have been instrumental in the elucidation of
the central cell-death machinery, which is conserved from C. elegans to mammals,. One …

Apoptosis is triggered when proapoptotic members of the Bcl-2 protein family bearing only
the BH3 association domain bind to Bcl-2 or its homologs and block their antiapoptotic …

Nods, a growing family of proteins containing a nucleotide-binding oligomerization domain
(NOD), are involved in the regulation of programmed cell death (PCD) and immune …

Apoptosis, a form of programmed cell death, is executed by a family of zymogenic proteases
known as caspases, which cleave an array of intracellular substrates in the dying cell. Many …

Interplay among four genes—egl-1, ced-9, ced-4 and ced-3—controls the onset of
programmed cell death in the nematode Caenorhabditis elegans. Activation of the cell …

Programmed cell death is an integral component of Caenorhabditis elegans development.
Genetic and reverse genetic studies in C. elegans have led to the identification of many …