RPE cells are the most actively phagocytic cells in the human body. In the eye, RPE cells
face rod and cone photoreceptor outer segments at all times but contribute to shedding and …

Pluripotent stem cells (PSCs) are a potential replacement tissue source for degenerative
diseases. Age-related macular degeneration (AMD) is a blinding disease triggered by …

Numerous protocols have been described for producing neural retina from human
pluripotent stem cells (hPSCs), many of which are based on the culture of 3D organoids …

Regional phenotypic and functional differences in the retinal pigment epithelium (RPE)
monolayer have been suggested to account for regional susceptibility in ocular diseases …

Mutations in pre-mRNA processing factors (PRPFs) cause autosomal-dominant retinitis
pigmentosa (RP), but it is unclear why mutations in ubiquitously expressed genes cause non …

The retinal pigment epithelium (RPE), a monolayer located between the photoreceptors and
the choroid, is constantly damaged by oxidative stress, particularly because of reactive …

Age‐related macular degeneration (AMD) is a leading cause of blindness worldwide.
Drusen are key contributors to the etiology of AMD and the ability to modulate drusen …

Transplantation of the retinal pigment epithelium (RPE) is being developed as a cell-
replacement therapy for age-related macular degeneration. Human embryonic stem cell …

Age-related macular degeneration (AMD) and related macular dystrophies (MDs) are a
major cause of vision loss. However, the mechanisms underlying their progression remain ill …

Background Human pluripotent stem cells (hPSCs) provide a promising cell source for
ocular cell replacement therapy, but often lack standardized and xenogeneic-free culture …