Although transcript levels have been traditionally used as a surrogate measure of gene
expression, it is increasingly recognized that the latter is extensively and dynamically …

Eukaryotic initiation factor 4E (eIF4E), a fundamental effector and rate limiting element of
protein synthesis, binds the 7‐methylguanosine cap at the 5′ end of eukaryotic messenger …

Background: Studies in multiple sclerosis (MS) and in experimental models point to a critical
role of semaphorin (sema) 3A and sema7A in MS pathogenesis. Objective: The objective of …

Colorectal cancer (CRC) is the third most common cause of cancer related death worldwide.
Furthermore, with more than 1.2 million cases registered per year, it constitutes the third …

Purpose Aberrant expression of eukaryotic initiation factor 4E (eIF4E) has been observed in
human malignancies. However, its role in hepatocellular carcinoma (HCC) remains to be …

Purpose Liver metastasis is one of the leading causes of death in colorectal cancer (CRC)
patients. The present study aimed to evaluate the value of eIF4E as a prognostic marker of …

Translation of mRNA is an important process that controls cell behavior and gene regulation
because proteins are the functional molecules that determine cell types and function …

Background: Hepatocellular carcinoma (HCC) is considered the most common type of liver
cancer and the fourth leading cause of cancer-related deaths in the world. Since the disease …

Both phosphorylated 4E binding protein 1 (p-4E-BP1) and eukaryotic translation initiation
factor 4E (eIF-4E) play an important role in cancer progression. The aim of this study is to …

As demonstrated in previous studies, the phosphorylated form of 4E‑binding protein 1 (p‑4E‑
BP1) may be a suitable tumor biomarker. The aim of the current study was to examine the …