Abstract CCN1 (CYR61) is a dynamically expressed, multifunctional matricellular protein
that plays essential roles in cardiovascular development during embryogenesis, and …

Members of the CCN (CYR61/CTGF/NOV) family have emerged as dynamically expressed,
extracellular matrix-associated proteins that play critical roles in cardiovascular and skeletal …

Several growth factors are expressed in distinct temporal and spatial patterns during fracture
repair. Of these, vascular endothelial growth factor, VEGF, is of particular interest because of …

Introduction This study presents a unifying concept of the pathophysiology of endometriosis
and adenomyosis. In particular, a physiological model is proposed that provides a …

The CCN family of genes presently consists of six distinct members encoding proteins that
participate in fundamental biological processes such as cell proliferation, attachment …

• Introduction• ECM: composition and structureCollagenLamininFibronectinElastin
NidogenGlycosaminoglycansPerlecanSyndecansReceptors for ECM molecules• …

Objective To understand changes in gene expression levels that occur during osteoarthritic
(OA) cartilage degeneration, using complementary DNA (cDNA)–array technology. Methods …

The healing of skeletal fractures is essentially a replay of bone development, involving the
closely regulated, interdependent processes of chondrogenesis and osteogenesis. Using a …

One of the immediate sequelae of bone fracture is regional hypoxia resulting from
vasculature disruption. Hypoxia stabilizes and activates the transcription factor hypoxia …

Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used for the treatment of
skeletal injuries. The ability of NSAIDs to reduce pain and inflammation is well-established …