Observing drugs and ligands at their site of action in membrane proteins is now possible
through the use of a development in biomolecular NMR spectroscopy known as solid-state …

Structure investigations of biological solids by high resolution MAS solid-state NMR have
rapidly progressed the last few years. These investigations recently resulted in the complete …

The general approach for obtaining NMR constraints essential for determination of 3D
structure of proteins as well as its theoretical background were already discussed in Section …

The nicotinic acetylcholine receptor is a prototype ligand-gated ion channel that mediates
signal transduction in the neuromuscular junctions and other cholinergic synapses. The …

Communication in the nervous system takes place at chemical and electrical synapses,
where neurotransmitter–gated ion channels, such as the nicotinic acetylcholine (ACh) …

We show in this communication that dynamic information for uniformly 2H, 13C, 15N
isotopically enriched, crystalline proteins can be obtained by MAS solid-state NMR …

Acetylcholine (ACh) is one of the intercellular neurotransmitters (NT) involved in the
transmission of nervous excitation in the central and peripheral nervous systems. Hydration …

Molecular dynamics simulations of a homology model of the ligand binding domain of the α7
nicotinic receptor are conducted with a range of bound ligands to induce different …

The interaction of lipids with subunit c from F 1 F 0 ATP synthase is studied by biophysical
methods. Subunit c from both Escherichia coli and Streptococcus pneumoniae interacts and …

19F NMR is a unique tool to examine the structure of fluorine-labeled peptides in their native
cellular environment, due to an exquisite sensitivity and lack of natural abundance …