Introduction: The amyloid hypothesis of Alzheimer's disease (AD) states that brain
accumulation of amyloid-β (Aβ) oligomers and soluble aggregates represents the major …

Summary β‐site amyloid precursor protein cleaving enzyme‐1 (BACE1) research has
historically focused on its actions as the β‐secretase responsible for the production of β …

Amyloid precursor protein (APP) is a transmembrane precursor protein that is widely
expressed in the central nervous system and peripheral tissues in the liver and pancreas …

The aggregation of amyloid-beta peptide and tau protein dysregulation are implicated to
play key roles in Alzheimer's disease pathogenesis and are considered the main …

Alzheimer's disease (AD) is one of the most devastating brain disorders. Currently, there are
no effective treatments to stop the disease progression and it is becoming a major public …

Alzheimer's disease (AD) diagnosis is based on invasive and expensive biomarkers.
Regarding AD pathophysiological mechanisms, there is evidence of a link between AD and …

Nowadays, Alzheimer's disease (AD) is a severe sociological and clinical problem. Since it
was first described, there has been a constant increase in its incidence and, for now, there …

Lipids are the major component of the brain with important structural and functional
properties. Lipid disruption could play a relevant role in Alzheimer's disease (AD). Some …

Abstract Background The prevalences of Alzheimer's disease (AD) and type 2 diabetes
(T2D) continuously increase with the aging of world population. Clinical and epidemiological …

Diabetes, obesity, and Alzheimer's disease (AD) are associated with vascular complications
and impaired nitric oxide (NO) production. Furthermore, increased β-site amyloid precursor …