Ocular drug delivery: a comprehensive review

S Ahmed, MM Amin, S Sayed - AAPS PharmSciTech, 2023 - Springer
The human eye is a sophisticated organ with distinctive anatomy and physiology that
hinders the passage of drugs into targeted ophthalmic sites. Effective topical administration …

Recent advances in ophthalmic preparations: Ocular barriers, dosage forms and routes of administration

FA Maulvi, KH Shetty, DT Desai, DO Shah… - International journal of …, 2021 - Elsevier
The human eye is a complex organ with unique anatomy and physiology that restricts the
delivery of drugs to target ocular tissues/sites. Recent advances in the field of pharmacy …

Advancements in rectal drug delivery systems: clinical trials, and patents perspective

R Rathi, Sanshita, A Kumar, V Vishvakarma… - Pharmaceutics, 2022 - mdpi.com
The rectal route is an effective route for the local and systemic delivery of active
pharmaceutical ingredients. The environment of the rectum is relatively constant with low …

Development of thermosensitive and mucoadhesive gels of cabotegravir for enhanced permeation and retention profiles in vaginal tissue: A proof of concept study

CK Enggi, HT Isa, S Sulistiawati, KAR Ardika… - International Journal of …, 2021 - Elsevier
As an effective anti-HIV drug, cabotegravir (CAB) is currently administered via oral and
injection routes, leading to several drawbacks, such as poor oral bioavailability and …

Lamotrigine-loaded poloxamer-based thermo-responsive sol–gel: formulation, in vitro assessment, ex vivo permeation, and toxicology study

M Riaz, M Zaman, H Hameed, HS Sarwar, MA Khan… - Gels, 2023 - mdpi.com
The present study aimed to prepare, characterize, and evaluate a thermo-responsive sol–
gel for intranasal delivery of lamotrigine (LTG), which was designed for sustained drug …

Tailored Doxycycline Hyclate Loaded In Situ Gel for the Treatment of Periodontitis: Optimization, In Vitro Characterization, and Antimicrobial Studies

KM Ranch, FA Maulvi, AR Koli, DT Desai, RK Parikh… - AAPS …, 2021 - Springer
Currently, periodontitis is treated by oral dosage forms (antibiotics) which shows systemic
side effects and failed to reach the therapeutic concentration (above minimum inhibitory …

[HTML][HTML] Recent advances in alginate based gastroretentive technologies for drug delivery applications

O Sen, S Manna, G Nandi, S Jana, S Jana - Medicine in Novel Technology …, 2023 - Elsevier
The efficacy of orally delivered medicines can be maximized through enhancing the gastric
residence period and modifying the drug release pattern according to therapeutic need …

[HTML][HTML] Gellan gum and sodium alginate in-situ gel of monocaprin for effective corneal permeation

S Giri, TS Markandeywar, Z Irfan, S Manna - Food Hydrocolloids for Health, 2023 - Elsevier
Babies born to mothers suffering from gonorrhea may experience severe eye infections that
might culminate in loss of vision. The eyes of the neonate can are infected with Neisseria …

Concentration of a microemulsion influences the mechanical properties of ibuprofen in situ microgels

R Hamed, Y Al-Adhami, R Abu-Huwaij - International Journal of …, 2019 - Elsevier
The aim of this study was to develop an ibuprofen microemulsion (IBU–ME) incorporated
into in situ gels (microgels) for local delivery into periodontal pockets. The IBU–ME was …

Evaluation of lectin nanoscaffold based in-situ gel against vulvovaginal candidiasis causing Candida biofilms using a novel ex-vivo model

J Senthilganesh, L Deepak, R Durai… - Journal of Drug Delivery …, 2022 - Elsevier
Vulvovaginal Candidiasis (VVC) remains a global issue for women of the reproductive age
group. It is mainly caused by Candida albicans and in some cases includes a co-infection …