In the past decade, multicomponent reactions have experienced a renaissance as powerful
peptide macrocyclization tools enabling the rapid creation of skeletal complexity and …

Conspectus Multicomponent reactions (MCRs) encompass an exciting class of chemical
transformations that have proven success in almost all fields of synthetic organic chemistry …

The epimerization-free formation of peptide bonds is crucial for the development of peptide
therapeutics and pharmaceuticals. Herein, we report a hydrosilane-mediated approach for …

Cancer is one of the diseases with the highest mortality rate. Treatments to mitigate cancer
are usually so intense and invasive that they weaken the patient to cure as dangerous as the …

Bioorthogonal reactions are valuable tools for the selective labeling and imaging of natural
products and proteins. Here, we present the reaction between isonitriles and chlorooximes …

Introduction: Multicomponent reactions are paramount in drug discovery for their ability to
achieve high levels of diversity within the chemical space, generating complex structures …

An electrochemical approach to peptide C-terminal N-acylpyrroles is described from readily
accessible C-terminal hydroxyproline-containing peptides, prepared via standard Fmoc …

2, 5-DKP scaffolds are widely used in medicinal chemistry as the basis for many bioactive
compounds. These scaffolds have a wide range of biological properties, offering numerous …

A new pathway towards enantiomerically pure 3-substituted piperazines, bearing a benzyl
protecting group, has been developed in good overall yields (83–92%), starting from …

Aiming at providing an efficient and versatile method for the diversity‐oriented decoration
and ligation of fullerenes, we report the first C60 derivatization strategy based on isocyanide …