Studies of 3D chromatin organization have suggested that chromosomes are hierarchically
organized into large compartments composed of smaller domains called topologically …

How cells adopt different identities has long fascinated biologists. Signal transduction in
response to environmental cues results in the activation of transcription factors that …

Motivation Generating publication ready plots to display multiple genomic tracks can pose a
serious challenge. Making desirable and accurate figures requires considerable effort. This …

Whereas folding of genomes at the large scale of epigenomic compartments and
topologically associating domains (TADs) is now relatively well understood, how chromatin …

Several recent studies in a number of model systems including zebrafish, Arabidopsis, and
mouse have revealed phenotypic differences between knockouts (ie, mutants) and …

Despite an abundance of new studies about topologically associating domains (TADs), the
role of genetic information in TAD formation is still not fully understood. Here we use our …

The spatial organization of the genome into compartments and topologically associated
domains can have an important role in the regulation of gene expression. But could gene …

Networks of regulatory enhancers dictate distinct cell identities and cellular responses to
diverse signals by instructing precise spatiotemporal patterns of gene expression. However …

The complex and dynamic three-dimensional organization of chromatin within the nucleus
makes understanding the control of gene expression challenging, but also opens up …

Genome function, replication, integrity, and propagation rely on the dynamic structural
organization of chromosomes during the cell cycle. Genome folding in interphase provides …