[HTML][HTML] Microglia states and nomenclature: A field at its crossroads
Microglial research has advanced considerably in recent decades yet has been constrained
by a rolling series of dichotomies such as" resting versus activated" and" M1 versus M2." …
by a rolling series of dichotomies such as" resting versus activated" and" M1 versus M2." …
Hallmarks of neurodegenerative diseases
DM Wilson, MR Cookson, L Van Den Bosch… - Cell, 2023 - cell.com
Decades of research have identified genetic factors and biochemical pathways involved in
neurodegenerative diseases (NDDs). We present evidence for the following eight hallmarks …
neurodegenerative diseases (NDDs). We present evidence for the following eight hallmarks …
Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease
Alzheimer's disease (AD) is characterized by synaptic loss, which can result from
dysfunctional microglial phagocytosis and complement activation. However, what signals …
dysfunctional microglial phagocytosis and complement activation. However, what signals …
Microglia regulate central nervous system myelin growth and integrity
NB McNamara, DAD Munro, N Bestard-Cuche… - Nature, 2023 - nature.com
Myelin is required for the function of neuronal axons in the central nervous system, but the
mechanisms that support myelin health are unclear. Although macrophages in the central …
mechanisms that support myelin health are unclear. Although macrophages in the central …
The complex role of tumor-infiltrating macrophages
Long recognized as an evolutionarily ancient cell type involved in tissue homeostasis and
immune defense against pathogens, macrophages are being re-discovered as regulators of …
immune defense against pathogens, macrophages are being re-discovered as regulators of …
Dissection of artifactual and confounding glial signatures by single-cell sequencing of mouse and human brain
A key aspect of nearly all single-cell sequencing experiments is dissociation of intact tissues
into single-cell suspensions. While many protocols have been optimized for optimal cell …
into single-cell suspensions. While many protocols have been optimized for optimal cell …
Microglia: Immune and non-immune functions
K Borst, AA Dumas, M Prinz - Immunity, 2021 - cell.com
As resident macrophages of the central nervous system (CNS), microglia are associated
with diverse functions essential to the developing and adult brain during homeostasis and …
with diverse functions essential to the developing and adult brain during homeostasis and …
Physiology and diseases of tissue-resident macrophages
Embryo-derived tissue-resident macrophages are the first representatives of the
haematopoietic lineage to emerge in metazoans. In mammals, resident macrophages …
haematopoietic lineage to emerge in metazoans. In mammals, resident macrophages …
[HTML][HTML] A human brain vascular atlas reveals diverse mediators of Alzheimer's risk
The human brain vasculature is of great medical importance: its dysfunction causes
disability and death, and the specialized structure it forms—the blood–brain barrier …
disability and death, and the specialized structure it forms—the blood–brain barrier …
Microglia in neuroinflammation and neurodegeneration: from understanding to therapy
L Muzio, A Viotti, G Martino - Frontiers in neuroscience, 2021 - frontiersin.org
Microglia are the resident macrophages of the central nervous system (CNS) acting as the
first line of defense in the brain by phagocytosing harmful pathogens and cellular debris …
first line of defense in the brain by phagocytosing harmful pathogens and cellular debris …