IL-17 and IL-17-producing cells in protection versus pathology

KHG Mills - Nature Reviews Immunology, 2023 - nature.com
IL-17 cytokine family members have diverse biological functions, promoting protective
immunity against many pathogens but also driving inflammatory pathology during infection …

The IL-17 family in diseases: from bench to bedside

L Huangfu, R Li, Y Huang, S Wang - Signal Transduction and Targeted …, 2023 - nature.com
Abstract The interleukin-17 (IL-17) family comprises six members (IL-17A–17F), and
recently, all of its related receptors have been discovered. IL-17 was first discovered …

Genetic variants associated with hidradenitis suppurativa

Q Sun, KA Broadaway, SN Edmiston… - JAMA …, 2023 - jamanetwork.com
Importance Hidradenitis suppurativa (HS) is a common and severely morbid chronic
inflammatory skin disease that is reported to be highly heritable. However, the genetic …

Biologics for hidradenitis suppurativa: evolution of the treatment paradigm

CA Maronese, C Moltrasio, G Genovese… - Expert Review of …, 2024 - Taylor & Francis
Introduction Hidradenitis suppurativa (HS) is an autoinflammatory skin disease with a high
unmet need for effective medical management. Clinically, it is characterized by inflammatory …

Risk of psoriasis in people with hidradenitis suppurativa: A systematic review and meta-analysis

SY Gau, IAC Preclaro, JCC Wei, CY Lee… - Frontiers in …, 2022 - frontiersin.org
Background Hidradenitis suppurativa were associated with comorbidities in various organ
systems. Inflammatory dermatological diseases such as pyoderma gangrenosum were …

Short-term effectiveness, safety, and potential predictors of response of secukinumab in patients with severe hidradenitis suppurativa refractory to biologic therapy: a …

P Fernandez-Crehuet, S Haselgruber… - Dermatology and …, 2023 - Springer
Introduction Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease. Biologic
drugs have a key role in the long-term anti-inflammatory treatment of moderate to severe …

An anti-interleukin-17A monoclonal antibody, ixekizumab, in the treatment of resistant hidradenitis suppurativa: a case series

P Esme, A Botsali, G Akoglu, E Caliskan - Skin Appendage Disorders, 2022 - karger.com
Introduction: Although adalimumab is the only approved biologic for the treatment of
hidradenitis suppurativa (HS), the treatment response may not be satisfactory in all patients …

Risk of liver dysfunction and non-alcoholic fatty liver diseases in people with hidradenitis suppurativa: A systematic review and meta-analysis of real-world evidences

SY Gau, YP Hsiao, WC Liao, KSK Ma… - Frontiers in …, 2022 - frontiersin.org
Background To date, evidences with high evidence-level evaluating the association
between liver diseases and hidradenitis suppurativa was lacking. Given that inconsistency …

The interleukine-17 cytokine family: role in development and progression of spondyloarthritis, current and potential therapeutic inhibitors

A Davydova, Y Kurochkina, V Goncharova… - Biomedicines, 2023 - mdpi.com
Spondyloarthritis (SpA) encompasses a group of chronic inflammatory rheumatic diseases
with a predilection for the spinal and sacroiliac joints, which include axial spondyloarthritis …

Hidradenitis suppurativa in children and adolescents: an update on pharmacologic treatment options

N Chiang, C Sibbald, R Levy, I Lara-Corrales - Pediatric Drugs, 2023 - Springer
Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory skin condition that
manifests as painful, deep-seated, inflamed nodules and abscesses in the axillary, groin …