Bacterial type II fatty acid synthesis (FASII) is a target for novel antibiotic development. All
bacteria encode for mechanisms to incorporate exogenous fatty acids, and some bacteria …

Highlights•Some persistent infections are linked to drug resistance and adverse outcomes
such as cancer.•Longitudinal human-infection studies offer access to early and late infection …

Persistent infections require bacteria to evolve from their naïve colonization state by
optimizing fitness in the host via simultaneous adaptation of multiple traits, which can …

The human microbiome harbours a large capacity for within-person adaptive mutations.
Commensal bacterial strains can stably colonize a person for decades, and billions of …

Hospital-associated infections are a major concern for global public health. Infections with
antibiotic-resistant pathogens can cause empiric treatment failure, and for infections with …

Within-host adaptation is a hallmark of chronic bacterial infections, involving substantial
genomic changes. Recent large-scale genomic data from prolonged infections allow the …

Background There is increased interest in bacteriophage (phage) therapy to treat infections
caused by antibiotic‐resistant bacteria. A lung transplant recipient with cystic fibrosis and …

There is an impending crisis in healthcare brought about by a new era of untreatable
infections caused by bacteria resistant to all available antibiotics. Thus, there is an urgent …

As opposed to acute respiratory infections, the persistent bacterial infections of the lung that
characterize cystic fibrosis (CF) provide ample time for bacteria to evolve and adapt. The …

Cystic fibrosis (CF) is a genetic disorder characterized by progressive lung function decline.
CF patients are at an increased risk of respiratory infections, including those by the …