Lipid droplets and liver disease: from basic biology to clinical implications

NL Gluchowski, M Becuwe, TC Walther… - Nature reviews …, 2017 - nature.com
Lipid droplets are dynamic organelles that store neutral lipids during times of energy excess
and serve as an energy reservoir during deprivation. Many prevalent metabolic diseases …

Genetic engineering of microalgae for enhanced lipid production

CF Muñoz, C Südfeld, MIS Naduthodi… - Biotechnology …, 2021 - Elsevier
Microalgae have the potential to become microbial cell factories for lipid production. Their
ability to convert sunlight and CO 2 into valuable lipid compounds has attracted interest from …

Biogenesis of the multifunctional lipid droplet: lipids, proteins, and sites

A Pol, SP Gross, RG Parton - Journal of Cell Biology, 2014 - rupress.org
Lipid droplets (LDs) are ubiquitous dynamic organelles that store and supply lipids in all
eukaryotic and some prokaryotic cells for energy metabolism, membrane synthesis, and …

Lipid droplet biogenesis

F Wilfling, JT Haas, TC Walther, RV Farese Jr - Current opinion in cell …, 2014 - Elsevier
Lipid droplets (LDs) are found in most cells, where they play central roles in energy and
membrane lipid metabolism. The de novo biogenesis of LDs is a fascinating, yet poorly …

A conserved family of proteins facilitates nascent lipid droplet budding from the ER

V Choudhary, N Ojha, A Golden, WA Prinz - Journal of Cell Biology, 2015 - rupress.org
Lipid droplets (LDs) are found in all cells and play critical roles in lipid metabolism. De novo
LD biogenesis occurs in the endoplasmic reticulum (ER) but is not well understood. We …

Plant lipid droplets and their associated proteins: potential for rapid advances

AHC Huang - Plant physiology, 2018 - academic.oup.com
Cytoplasmic lipid droplets (LDs) of neutral lipids (triacylglycerols [TAGs], sterylesters, etc.)
are reserves of high-energy metabolites and other constituents for future needs. They are …

The lipid droplet—a well-connected organelle

Q Gao, JM Goodman - Frontiers in cell and developmental biology, 2015 - frontiersin.org
Our knowledge of inter-organellar communication has grown exponentially in recent years.
This review focuses on the interactions that cytoplasmic lipid droplets have with other …

Lipid droplet and peroxisome biogenesis occur at the same ER subdomains

AS Joshi, B Nebenfuehr, V Choudhary… - Nature …, 2018 - nature.com
Nascent lipid droplet (LD) formation occurs in the endoplasmic reticulum (ER) membrane
but it is not known how sites of biogenesis are determined. We previously identified ER …

The perilipins: major cytosolic lipid droplet–associated proteins and their roles in cellular lipid storage, mobilization, and systemic homeostasis

AR Kimmel, C Sztalryd - Annual review of nutrition, 2016 - annualreviews.org
The discovery by Dr. Constantine Londos of perilipin 1, the major scaffold protein at the
surface of cytosolic lipid droplets in adipocytes, marked a fundamental conceptual change in …

Structural insights into perilipin 3 membrane association in response to diacylglycerol accumulation

YM Choi, D Ajjaji, KD Fleming, PP Borbat… - Nature …, 2023 - nature.com
Lipid droplets (LDs) are dynamic organelles that contain an oil core mainly composed of
triglycerides (TAG) that is surrounded by a phospholipid monolayer and LD-associated …