Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …

Breakthroughs in molecular medicine have positioned the amyloid-β (Aβ) pathway at the
center of Alzheimer's disease (AD) pathophysiology. While the detailed molecular …

In presymptomatic Alzheimer's disease (AD), beta-amyloid plaques (Aβ) and tau tangles
accumulate in distinct spatiotemporal patterns within the brain, tracking closely with episodic …

Cross-sectional studies have consistently identified age-associated alterations in default
mode network (DMN) functional connectivity (FC). Yet, research on longitudinal trajectories …

Co-occurrence of beta amyloid (Aβ) and white matter hyperintensities (WMHs) increase the
risk of dementia and both are considered biomarkers of preclinical dementia. Moderation …

Greater physical activity and better sleep are associated with reduced risk of cognitive
decline and dementia among older adults, but little is known about their combined …

Background: Recently, a new resting-state functional magnetic resonance imaging (rs-fMRI)
measure to evaluate the concordance between different rs-fMRI metrics has been proposed …

Recent studies have demonstrated the pivotal role of locus coeruleus (LC) and salience
network (SN) resting state functional connectivity (rsFC) changes in the early stage of …

Age-related cognitive decline is related to cellular and systems-level disruptions across
multiple brain regions. Because age-related cellular changes within different structures do …

Background: The association between regional volumes and resting-state functional
networks was tested within the default-mode network (DMN), influenced by Alzheimer …