Transcription factors/activators are a group of proteins that bind to specific consensus
sequences (cis elements) in the promoter regions of downstream target/effector genes and …

Abstract 17β-Estradiol (E2) binds to the estrogen receptor (ER) to activate gene expression
or repression and this involves both genomic (nuclear) and non-genomic (extranuclear …

In aged mice, the redox-regulated transcription factor nuclear factor-κB (NF-κB) becomes
constitutively active in many tissues, as well as in cells of the hematopoietic system. This …

Actual fields of research in neurobiology are not only aimed at understanding the different
aspects of brain aging but also at developing strategies useful to preserve brain …

Oxidative stress is a host defense mechanism whose involvement in maintaining
homeostasis and/or inducing disease has been widely investigated over the past decade …

Reactive oxygen species (ROS) are produced by cellular metabolic reactions, and have
been implicated in the pathogenesis of several diseases, including atherosclerosis, cancer …

The discovery of some additional properties and functions of reactive oxygen species (ROS),
beyond their toxic effects, provides a novel scenario for the molecular basis and cell …

Both the aging of animals and the senescence of cultured cells involve an altered pattern of
gene expression, suggesting changes in transcription factor regulation. We studied age …

Background Curcumin inhibits growth of several cancer cell lines, and studies in this
laboratory in bladder and pancreatic cancer cells show that curcumin downregulates …

The proteolytical processing of the amyloid precursor protein (APP) gives rise to β-amyloid
peptides, which accumulate in brains of Alzheimer's disease (AD) patients. Different soluble …