In type 1 diabetes, the reduced glucagon response to insulin-induced hypoglycemia has
been used to argue that β-cell secretion of insulin is required for the full glucagon …

Obesity is a metabolic state of energy excess and a risk factor for over a dozen cancer types.
Because of the rising worldwide prevalence of obesity, decoding the mechanisms by which …

RNA hybridization‐based spatial transcriptomics provides unparalleled detection sensitivity.
However, inaccuracies in segmentation of image volumes into cells cause misassignment of …

Tissue repair responses in metazoans are highly coordinated by different cell types over
space and time. However, comprehensive single-cell-based characterization covering this …

MODY8 (maturity-onset diabetes of the young, type 8) is a dominantly inherited monogenic
form of diabetes associated with mutations in the carboxyl ester lipase (CEL) gene …

Summary Type 1 (T1D) or type 2 diabetes (T2D) are caused by a deficit of functional insulin-
producing β cells. Thus, the identification of β cell trophic agents could allow the …

An increasing number of studies have demonstrated that disease states of the endocrine or
exocrine pancreas aggravate one another, which implies bidirectional blood flow between …

Loss of functional pancreatic β-cell mass and increased β-cell apoptosis are fundamental to
the pathophysiology of type 1 and type 2 diabetes. Pancreatic islet transplantation has the …

The endocrine and exocrine pancreas have been studied separately by endocrinologists
and gastroenterologists as two organ systems. The pancreatic islet, consisting of 1–2 …

Cellular crosstalk plays a vital role in maintaining pancreas homeostasis. Recently, in Cell
Metabolism, Basile et al. demonstrated that aberrant upregulation of acinar-cell-specific …