[HTML][HTML] Viral membrane fusion: a dance between proteins and lipids
There are at least 21 families of enveloped viruses that infect mammals, and many contain
members of high concern for global human health. All enveloped viruses have a dedicated …
members of high concern for global human health. All enveloped viruses have a dedicated …
Distinguishing features of fold‐switching proteins
Though many folded proteins assume one stable structure that performs one function, a
small‐but‐increasing number remodel their secondary and tertiary structures and change …
small‐but‐increasing number remodel their secondary and tertiary structures and change …
Identification of a conserved S2 epitope present on spike proteins from all highly pathogenic coronaviruses
To address the ongoing SARS-CoV-2 pandemic and prepare for future coronavirus
outbreaks, understanding the protective potential of epitopes conserved across SARS-CoV …
outbreaks, understanding the protective potential of epitopes conserved across SARS-CoV …
[HTML][HTML] Structural dynamics in the evolution of SARS-CoV-2 spike glycoprotein
V Calvaresi, AG Wrobel, J Toporowska… - Nature …, 2023 - nature.com
SARS-CoV-2 spike glycoprotein mediates receptor binding and subsequent membrane
fusion. It exists in a range of conformations, including a closed state unable to bind the ACE2 …
fusion. It exists in a range of conformations, including a closed state unable to bind the ACE2 …
[HTML][HTML] Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level
Recent waves of COVID-19 correlate with the emergence of the Delta and the Omicron
variant. We report that the Spike trimer acts as a highly dynamic molecular caliper, thereby …
variant. We report that the Spike trimer acts as a highly dynamic molecular caliper, thereby …
[HTML][HTML] Prefusion-stabilized SARS-CoV-2 S2-only antigen provides protection against SARS-CoV-2 challenge
Abstract Ever-evolving SARS-CoV-2 variants of concern (VOCs) have diminished the
effectiveness of therapeutic antibodies and vaccines. Developing a coronavirus vaccine that …
effectiveness of therapeutic antibodies and vaccines. Developing a coronavirus vaccine that …
Timeline of changes in spike conformational dynamics in emergent SARS-CoV-2 variants reveal progressive stabilization of trimer stalk with altered NTD dynamics
SARS-CoV-2 emergent variants are characterized by increased viral fitness and each shows
multiple mutations predominantly localized to the spike (S) protein. Here, amide …
multiple mutations predominantly localized to the spike (S) protein. Here, amide …
[HTML][HTML] Discovery and multimerization of cross-reactive single-domain antibodies against SARS-like viruses to enhance potency and address emerging SARS-CoV-2 …
SA Hollingsworth, CL Noland, K Vroom, A Saha… - Scientific Reports, 2023 - nature.com
Coronaviruses have been the causative agent of three epidemics and pandemics in the past
two decades, including the ongoing COVID-19 pandemic. A broadly-neutralizing …
two decades, including the ongoing COVID-19 pandemic. A broadly-neutralizing …
[HTML][HTML] Balancing functional tradeoffs between protein stability and ACE2 binding in the SARS-CoV-2 omicron BA. 2, BA. 2.75 and XBB lineages: dynamics-based …
G Verkhivker, M Alshahrani, G Gupta - Viruses, 2023 - mdpi.com
Evolutionary and functional studies suggested that the emergence of the Omicron variants
can be determined by multiple fitness trade-offs including the immune escape, binding …
can be determined by multiple fitness trade-offs including the immune escape, binding …
Markov State Models and Perturbation-Based Approaches Reveal Distinct Dynamic Signatures and Hidden Allosteric Pockets in the Emerging SARS-Cov-2 Spike …
The new generation of SARS-CoV-2 Omicron variants displayed a significant growth
advantage and increased viral fitness by acquiring convergent mutations, suggesting that …
advantage and increased viral fitness by acquiring convergent mutations, suggesting that …