Integrins mediate cell adhesion and transmit mechanical and chemical signals to the cell
interior. Various mechanisms deregulate integrin signaling in cancer, empowering tumor …

As our understanding of cancer cell biology progresses, it has become clear that tumors are
a heterogenous mixture of different cell populations, some of which contain so called …

Integrins are vital surface adhesion receptors that mediate interactions between the
extracellular matrix (ECM) and cells and are essential for cell migration and the …

Simple Summary Integrins, a superfamily of cell adhesion receptors, were extensively
investigated as therapeutic targets over the last decades, motivated by their multiple …

Interactions between cancer cells and their surroundings can trigger essential signaling
cues that determine cell fate and influence the evolution of the malignant phenotype. As the …

The function of vascular endothelial growth factor (VEGF) in cancer is not limited to
angiogenesis and vascular permeability. VEGF-mediated signalling occurs in tumour cells …

During mammalian embryonic development, primary cilia transduce and regulate several
signaling pathways. Among the various pathways, Sonic hedgehog (SHH) is one of the most …

Triple-negative breast cancer (TNBC) is the most complex, aggressive and fatal subtype of
breast cancer. Owing to the lack of targeted therapy and heterogenic nature of TNBC …

Breast cancer is the second common cancer and the leading cause of malignancy among
females overall. Breast cancer stem cells (BCSCs) are a small population of breast cancer …

Although blocking the binding of vascular endothelial growth factor (VEGF) to neuropilin-2
(NRP2) on tumor cells is a potential strategy to treat aggressive carcinomas, a lack of …