Neurodevelopmental abnormalities and congenital heart disease: insights into altered brain maturation

PD Morton, N Ishibashi, RA Jonas - Circulation research, 2017 - Am Heart Assoc
In the past 2 decades, it has become evident that individuals born with congenital heart
disease (CHD) are at risk of developing life-long neurological deficits. Multifactorial risk …

Brain injury and neurodevelopmental outcome in congenital heart disease: a systematic review

MJ Mebius, EMW Kooi, CM Bilardo, AF Bos - Pediatrics, 2017 - publications.aap.org
OBJECTIVE: To assess the association between prenatal and postnatal preoperative
cerebral findings and NDO in infants with CHD who require corrective or palliative surgery …

Optimizing neurodevelopmental outcomes in neonates with congenital heart disease

CM Ortinau, CD Smyser, L Arthur, EE Gordon… - …, 2022 - publications.aap.org
Neurodevelopmental impairment is a common and important long-term morbidity among
infants with congenital heart disease (CHD). More than half of those with complex CHD will …

Prevalence of prenatal brain abnormalities in fetuses with congenital heart disease: a systematic review

A Khalil, S Bennet, B Thilaganathan… - … in Obstetrics & …, 2016 - Wiley Online Library
Objectives Studies have shown an association between congenital heart defects (CHDs)
and postnatal brain abnormalities and neurodevelopmental delay. Recent evidence …

Abnormal extracardiac development in fetuses with congenital heart disease

GO Dovjak, T Zalewski, E Seidl-Mlczoch, PA Ulm… - Journal of the American …, 2021 - jacc.org
Background Knowledge about extracardiac anomalies (ECA) in fetal congenital heart
disease (CHD) can improve our understanding of the developmental origins of various …

Neurodevelopmental outcome of children with congenital heart disease

R Liamlahi, B Latal - Handbook of clinical neurology, 2019 - Elsevier
Congenital heart disease (CHD) constitutes the most common congenital malformation, with
moderate or severe CHD occurring in around 6 in 1000 live births. Due to advances in …

De novo damaging variants associated with congenital heart diseases contribute to the connectome

W Ji, D Ferdman, J Copel, D Scheinost, V Shabanova… - Scientific reports, 2020 - nature.com
Congenital heart disease (CHD) survivors are at risk for neurodevelopmental disability
(NDD), and recent studies identify genes associated with both disorders, suggesting that …

Fetal postmortem imaging: an overview of current techniques and future perspectives

X Kang, A Carlin, MM Cannie, TC Sanchez… - American Journal of …, 2020 - Elsevier
Fetal death because of miscarriage, unexpected intrauterine fetal demise, or termination of
pregnancy is a traumatic event for any family. Despite advances in prenatal imaging and …

Neuroimaging, cardiovascular physiology, and functional outcomes in infants with congenital heart disease

NHP Claessens, CJ Kelly, SJ Counsell… - … Medicine & Child …, 2017 - Wiley Online Library
This review integrates data on brain dysmaturation and acquired brain injury using fetal and
neonatal magnetic resonance imaging (MRI), including the contribution of cardiovascular …

Harnessing the power of advanced fetal neuroimaging to understand in utero footprints for later neuropsychiatric disorders

J De Asis-Cruz, C Limperopoulos - Biological psychiatry, 2023 - Elsevier
Adverse intrauterine events may profoundly impact fetal risk for future adult diseases. The
mechanisms underlying this increased vulnerability are complex and remain poorly …