Intervertebral disc degeneration (IVDD) has been the major contributor to chronic lower back
pain (LBP). Abnormal apoptosis, senescence, and pyroptosis of IVD cells, extracellular …

Intervertebral disc degeneration (IVDD) is a common pathological condition responsible for
lower back pain, which can significantly increase economic and social burdens. Although …

Iron overload is a common phenomenon in the elderly population. Many clinical studies
have indicated an association between iron overload and the incidence and pathological …

Minimally invasive biodegradable implants with regeneration have been a frontier trend in
clinic. Degeneration of nucleus pulposus (NP) is irreversible in most of spine diseases, and …

Ferroptosis, as an iron‐dependent form of necrotic cell death, has been reported to affect
activities of nucleus pulposus cells (NPCs). However, its role in the pathogenesis of …

Cartilage endplate (CEP) plays important roles in the onset and progression of intervertebral
disc degeneration (IVDD). Icariin (ICA) is the major active ingredient of Herba Epimedii and …

Chronic low back pain and dyskinesia caused by intervertebral disc degeneration (IDD) are
seriously aggravated and become more prevalent with age. Current clinical treatments do …

Ferroptosis, an iron-dependent form of programmed cell death marked by phospholipid
peroxidation, is regulated by complex cellular metabolic pathways including lipid …

Back and neck pain have become a primary cause of disability and healthcare spending
globally. While the causes of back pain are multifactorial, intervertebral disc degeneration is …

The cartilaginous endplates (CEP) are key components of the intervertebral disc (IVD)
necessary for sustaining the nutrition of the disc while distributing mechanical loads and …