Members of the HECT family of E3 ubiquitin-protein ligases are characterized by a C-
terminal HECT domain that catalyzes the covalent attachment of ubiquitin to substrate …

The members of the Bcl-2 family are the central regulators of various cell death modalities.
Some of these proteins contribute to apoptosis, while others counteract this type of …

Hepatic ischemia followed by reperfusion (I/R), a major clinical problem during liver surgical
procedures, can induce liver injury with severe cell death including ferroptosis which is …

Abstract MCL-1, an anti-apoptotic BCL-2 family member that is essential for the survival of
multiple cell lineages, is also among the most highly amplified genes in cancer. Although …

Polyubiquitin chains of different topologies regulate diverse cellular processes. K48-and
K63-linked chains, the two most abundant chain types, regulate proteolytic and signaling …

BCL-2 molecules are regulators of programmed cell death and defects in this pathway
contribute to human diseases. One family member, MCL-1, is unique because its expression …

Mcl-1 is an anti-apoptotic protein of the Bcl-2 family that is essential for the survival of
multiple cell lineages and that is highly amplified in human cancer. Under physiological …

The disproportionately high prevalence of male cancer is poorly understood. We tested for
sex-disparity in the functional integrity of the major tumor suppressor p53 in sporadic …

Tumorigenesis results from dysregulation of oncogenes and tumor suppressors that
influence cellular proliferation, differentiation, apoptosis, and/or senescence. Many gene …

Regulatory functions of the ubiquitin-proteasome system (UPS) are exercised mainly by the
ubiquitin ligases and deubiquitinating enzymes. Degradation of apoptotic proteins by UPS is …