Cells encode information in the sequence of biopolymers, such as nucleic acids, proteins,
and glycans. Although glycans are essential to all living organisms, surprisingly little is …

Carbohydrates possess a variety of distinct features with stereochemistry playing a
particularly important role in distinguishing their structure and function. Monosaccharide …

Deciphering the carbohydrate alphabet is problematic due to its unique complexity among
biomolecules. Strikingly, routine sequencing technologies—which are available for proteins …

The analysis of carbohydrates, or glycans, is challenging for established structure-sensitive
gas-phase methods. The multitude of possible stereo-, regio-, and structural isomers makes …

Infrared (IR) spectroscopy is a powerful tool used to infer detailed structural information on
molecules, often in conjunction with quantum-chemical calculations. When applied to …

Although there have been substantial improvements in glycan analysis over the past
decade, the lack of both high-resolution and high-throughput methods hampers progress in …

The vast array of molecular isomerisms which form the complex molecular structure of
carbohydrates is the foundation of their biological versatility but defies the analytical chemist …

Glycans are intrinsically complex biomolecules that pose particular analytical challenges.
Standard workflows for glycan analysis are based on mass spectrometry, often coupled with …

Glycans, carbohydrates, and glycoconjugates are involved in many crucial biological
processes, such as disease development, immune responses, and cell–cell recognition …

Infrared ion spectroscopy is increasingly recognized as a method to identify mass
spectrometry-detected analytes in many (bio) chemical areas and its integration in analytical …