Numerous studies demonstrated that membrane cholesterol is a major regulator of ion
channel function. The goal of this review is to discuss significant advances that have been …

A variety of ion channels, including members of all major ion channel families, have been
shown to be regulated by changes in the level of membrane cholesterol and partition into …

NITRIC oxide is the major endothelium-derived relaxing factor (EDRF) 1–3, and it is thought
to relax smooth muscle cells by stimulation of guanylate cyclase, accumulation of its product …

A variety of fatty acids regulate the activity of specific ion channels by mechanisms not
involving the enzymatic pathways that convert arachidonic acid to oxygenated metabolites …

Fluid shear stress (FSS) has been shown to be an ubiquitous stimulator of mammalian cell
metabolism. Although many of the intracellular signal transduction pathways have been …

Alterations in the stiffness of lipid bilayers are likely to constitute a general mechanism for
modulation of membrane protein function. Gramicidin channels can be used as molecular …

All living cells interact dynamically with a constantly changing world. Eukaryotes, in
particular, evolved radically new ways to sense and react to their environment. These …

As described in the literature the interaction between cholesterol and membrane proteins
can occur via direct, ligand-like and indirect mechanisms, in which cholesterol effects are …

Ion transport across cell membranes is essential to cell communication and signaling.
Passive ion transport is mediated by ion channels, membrane proteins that create ion …

Activation of volume-regulated anion current (VRAC) plays a key role in the maintenance of
cellular volume homeostasis. The mechanisms, however, that regulate VRAC activity are not …