Isatin (1H-indole-2, 3-dione) and its derivatives represent an important class of heterocyclic
compounds that can be used as precursors for drug synthesis. Since its discovery, a lot of …

In recent years, spiro compounds have attracted significant interest in medicinal chemistry
due to their numerous biological activities attributed primarily to their versatility and structural …

In the current medical era, spirooxindole motif stands out as a privileged heterospirocyclic
scaffold that represents the core for a wide range of bioactive naturally isolated products …

Poor pharmacokinetic and safety profiles create significant hurdles in the drug development
process. This work focuses on a detailed understanding of drug discovery interplay among …

A transition-metal and hydride-free reductive aldol reaction has been developed for the
synthesis of biologically active 3, 3′-disubstituted oxindoles from isatin derivatives using …

N-Substituted succinimides having different alkyl groups were prepared by the reaction of N-
substituted maleimide with aldehydes. A two-component catalyst system composed of an …

Hydroxyapatite (HAp) derived from bioresources has garnered attention due to its
advantageous catalytic capabilities. In this study, HAp was synthesized from green mussel …

An unexpected regio-and stereoselective [4+ 3] cycloaddition reaction of azomethine ylides
with 5-benzylidenethiazolidine-2, 4-diones has been successfully developed for the …

A series of ketonitrones derived from isatin and indanone (INs) were synthesized and
evaluated for their antiproliferative activities against several human cancer cell lines. Then …

A variety of (E)‐N‐aryloxindole nitrones were prepared in good to excellent yields by using a
copper‐catalyzed coupling reaction of isatin oximes and arylboronic acids under mild …