Interleukin-1 beta (IL-1β) is induced by inflammatory signals in a broad number of immune
cell types. IL-1β (and IL-18) are the only cytokines which are processed by caspase-1 after …

Vitiligo is a noncontagious autoimmune skin depigmenting disease. Regulatory T cells
(Tregs) play a key role in maintaining peripheral tolerance; however, Tregs' number …

The pathophysiology of vitiligo is complex although recent research has discovered several
markers which are linked to vitiligo and associated with disease activity. Besides providing …

Tumor necrosis factor-α (TNF-α) is a major mediator of inflammation and its increased levels
have been analyzed in vitiligo patients. Vitiligo is a depigmentary skin disarray caused due …

Generalized vitiligo (GV) is an autoimmune skin depigmenting disease characterized by loss
of functional melanocytes. Nuclear factor of activated T cells (NFATs) play a key role in …

Background Vitiligo is a depigmenting disorder resulting from loss of functional melanocytes
in the skin. NPY plays an important role in induction of immune response by acting on a …

Background Polymorphisms of NLR (nucleotide‐binding domain and leucine rich repeat
containing) family, pyrin domain containing protein 1 (NLRP1) have been found in patients …

Vitiligo is an autoimmune progressive skin depigmenting disease. Tumor necrosis factor
alpha (TNF-α) is a pro-inflammatory cytokine and plays a crucial role in vitiligo development …

Autoimmunity eventuates when the immune system attacks self-molecules as a result of the
breakdown in immune tolerance. Targeting autoimmune diseases via immunomodulation …

Activation of the NLRP3 inflammasome, a multiprotein complex, leading to caspase
activation with production of proinflammatory IL-1β represents a major pathway of …