Unravelling cell migration: defining movement from the cell surface

F Merino-Casallo, MJ Gomez-Benito… - Cell adhesion & …, 2022 - Taylor & Francis
Cell motility is essential for life and development. Unfortunately, cell migration is also linked
to several pathological processes, such as cancer metastasis. Cells' ability to migrate relies …

Tension, contraction and tissue morphogenesis

NC Heer, AC Martin - Development, 2017 - journals.biologists.com
D'Arcy Thompson was a proponent of applying mathematical and physical principles to
biological systems, an approach that is becoming increasingly common in developmental …

[HTML][HTML] Actomyosin meshwork mechanosensing enables tissue shape to orient cell force

S Chanet, CJ Miller, ED Vaishnav, B Ermentrout… - Nature …, 2017 - nature.com
Sculpting organism shape requires that cells produce forces with proper directionality. Thus,
it is critical to understand how cells orient the cytoskeleton to produce forces that deform …

[HTML][HTML] Tensional homeostasis in single fibroblasts

KD Webster, WP Ng, DA Fletcher - Biophysical journal, 2014 - cell.com
Adherent cells generate forces through acto-myosin contraction to move, change shape, and
sense the mechanical properties of their environment. They are thought to maintain defined …

Phase-field modeling of individual and collective cell migration

A Moure, H Gomez - Archives of Computational Methods in Engineering, 2021 - Springer
Cell motion is crucial in human health and development. Cells may migrate individually or in
highly coordinated groups. Cell motion results from complex intra-and extra-cellular …

[HTML][HTML] Interplay of active processes modulates tension and drives phase transition in self-renewing, motor-driven cytoskeletal networks

M Mak, MH Zaman, RD Kamm, T Kim - Nature communications, 2016 - nature.com
The actin cytoskeleton—a complex, nonequilibrium network consisting of filaments, actin-
crosslinking proteins (ACPs) and motors—confers cell structure and functionality, from …

[HTML][HTML] Isoforms confer characteristic force generation and mechanosensation by myosin II filaments

S Stam, J Alberts, ML Gardel, E Munro - Biophysical journal, 2015 - cell.com
Myosin II isoforms with varying mechanochemistry and filament size interact with filamentous
actin (F-actin) arrays to generate contractile forces in muscle and nonmuscle cells. How …

Cells as liquid motors: Mechanosensitivity emerges from collective dynamics of actomyosin cortex

J Étienne, J Fouchard, D Mitrossilis… - Proceedings of the …, 2015 - National Acad Sciences
Living cells adapt and respond actively to the mechanical properties of their environment. In
addition to biochemical mechanotransduction, evidence exists for a myosin-dependent …

Phase-field model of cellular migration: Three-dimensional simulations in fibrous networks

A Moure, H Gomez - Computer Methods in Applied Mechanics and …, 2017 - Elsevier
Cell motion plays a key role in many biological processes. Computational models are
gaining momentum as a tool that allows a quantitative understanding of the main biological …

[HTML][HTML] Morphological transformation and force generation of active cytoskeletal networks

TC Bidone, W Jung, D Maruri, C Borau… - PLoS computational …, 2017 - journals.plos.org
Cells assemble numerous types of actomyosin bundles that generate contractile forces for
biological processes, such as cytokinesis and cell migration. One example of contractile …