Despite recent developments in innovative treatment strategies, stroke remains one of the
leading causes of death and disability worldwide. Stem cell therapy is currently attracting …

Ischemic stroke is responsible for many deaths and long-term disability world wide.
Development of effective therapy has been the target of intense research. Accumulating …

AIMS: To identify better cells for the treatment of diabetic critical limb ischemia (CLI) and foot
ulcer in a pilot trial. METHODS: Under ordinary treatment, the limbs of 41 type 2 diabetic …

We demonstrate that tissue plasminogen activator (tPA) and its inhibitors contribute to
neurite outgrowth in the central nervous system (CNS) after treatment of stroke with …

The use of biologics in various diseases has dramatically increased in recent years. Stroke,
a cerebrovascular disease, is the second most common cause of death, and the leading …

Cell-based therapy is considered to be a promising therapeutic strategy for stroke treatment.
Although unfractionated bone marrow mononuclear cells (BMMNCs) have been tried in both …

Multipotent mesenchymal stromal cells (MSCs) increase tissue plasminogen activator (tPA)
activity in astrocytes of the ischemic boundary zone, leading to increased neurite outgrowth …

The donor cell culture in animal serum-free medium is quite important for the clinical
application of cell transplantation therapy. This study was aimed to test the hypothesis that …

Clinical trials of cell therapy in stroke favor autologous cell transplantation. To date,
feasibility studies have used bone marrow‐derived mononuclear cells, but harvesting bone …

Recent studies have elucidated that transplantation of the bone marrow stromal cells
(BMSC) has therapeutic potential for the central nervous system (CNS) disorders. However …