Glycomimetics versus multivalent glycoconjugates for the design of high affinity lectin ligands

S Cecioni, A Imberty, S Vidal - Chemical reviews, 2015 - ACS Publications
One could certainly highlight a conceptual resemblance between social interactions as the
basis of societies and civilizations and the ability of molecules to interact in a noncovalent …

Glycopolymer probes of signal transduction

LL Kiessling, JC Grim - Chemical Society Reviews, 2013 - pubs.rsc.org
Glycans are key participants in biological processes ranging from reproduction to cellular
communication to infection. Revealing glycan roles and the underlying molecular …

Modular synthesis of amphiphilic Janus glycodendrimers and their self-assembly into glycodendrimersomes and other complex architectures with bioactivity to …

V Percec, P Leowanawat, HJ Sun… - Journal of the …, 2013 - ACS Publications
The modular synthesis of 7 libraries containing 51 self-assembling amphiphilic Janus
dendrimers with the monosaccharides d-mannose and d-galactose and the disaccharide d …

Multivalent glycosystems for human lectins

M Martínez-Bailén, J Rojo… - Chemical Society …, 2023 - pubs.rsc.org
Human lectins are involved in a wide variety of biological processes, both physiological and
pathological, which have attracted the interest of the scientific community working in the …

Targeting C-type lectin receptors with multivalent carbohydrate ligands

B Lepenies, J Lee, S Sonkaria - Advanced drug delivery reviews, 2013 - Elsevier
C-type lectin receptors (CLRs) represent a large receptor family including collectins,
selectins, lymphocyte lectins, and proteoglycans. CLRs share a structurally homologous …

Glycofullerenes inhibit viral infection

J Luczkowiak, A Munoz, M Sanchez-Navarro… - …, 2013 - ACS Publications
Water-soluble glycofullerenes based on a hexakis-adduct of [60] fullerene with an
octahedral addition pattern are very attractive compounds providing a spherical presentation …

Dendritic cell-targeting polymer nanoparticle-based immunotherapy for cancer: A review

Y Hu, W Zhang, X Chu, A Wang, Z He, CL Si… - International Journal of …, 2023 - Elsevier
Cancer immunity is dependent on dynamic interactions between T cells and dendritic cells
(DCs). Polymer-based nanoparticles target DC receptors to improve anticancer immune …

Cross-presentation through langerin and DC-SIGN targeting requires different formulations of glycan-modified antigens

CM Fehres, H Kalay, SCM Bruijns… - Journal of controlled …, 2015 - Elsevier
Abstract Dendritic cells (DCs) and Langerhans cells (LC) are professional antigen
presenting cells (APCs) that initiate humoral and cellular immune responses. Targeted …

Glycodendritic structures as DC-SIGN binders to inhibit viral infections

J Ramos-Soriano, J Rojo - Chemical Communications, 2021 - pubs.rsc.org
DC-SIGN, a lectin discovered two decades ago, plays a relevant role in innate immunity.
Since its discovery, it has turned out to be a target for developing antiviral drugs based on …

Multivalent glycosylation of fluorescent gold nanoclusters promotes increased human dendritic cell targeting via multiple endocytic pathways

X Le Guével, M Perez Perrino… - … applied materials & …, 2015 - ACS Publications
We report the synthesis and characterization of gold nanoclusters (Au NCs) stabilized by a
mixture of zwitterionic and multivalent mannose ligands. Characterization of this …