The maintenance and preservation of distinct phases during the cell cycle is a highly
complex and coordinated process. It is regulated by phosphorylation—through the activity of …

In normal prostate, neuroendocrine (NE) cells are rare and interspersed among the
epithelium. These cells are believed to provide trophic signals to epithelial cell populations …

MicroRNAs (miRNAs) are implicated in both tissue differentiation and maintenance of tissue
identity. In most cases, however, the mechanisms underlying their regulation are not known …

Protein complexes that contain chromatin-modifying enzymes have an important role in
regulating gene expression. Recent studies have shown that a single transcription factor, the …

The neuronal repressor REST (RE1-silencing transcription factor; also called NRSF) is
expressed at high levels in mouse embryonic stem (ES) cells, but its role in these cells is …

The RE1-silencing transcription factor (REST, also known as NRSF) is a master repressor of
neuronal gene expression and neuronal programmes in non-neuronal lineages,,. Recently …

Transforming growth factor-beta (TGF-β) is a member of a family of secreted cytokines with
vital biological functions in cells. The abnormal expression of TGF-β signaling is a common …

Medulloblastoma is an aggressive brain malignancy with high incidence in childhood.
Current treatment approaches have limited efficacy and severe side effects. Therefore, new …

The repressor element 1-silencing transcription factor (REST) functions as a master
regulator to maintain neural stem/progenitor cells (NPCs). REST undergoes proteasomal …

Abstract REST/NRSF (repressor-element-1-silencing transcription factor/neuron-restrictive
silencing factor) negatively regulates the transcription of genes containing RE1 sites,. REST …