Effective metabolism is highly dependent on a narrow therapeutic range of oxygen.
Accordingly, low levels of oxygen, or hypoxia, are one of the most powerful inducers of gene …

Hyperbaric oxygen treatment (HBOT)—the medical use of oxygen at environmental pressure
greater than one atmosphere absolute—is a very effective therapy for several approved …

Sodium butyrate, a short-chain fatty acid, is predominantly produced by gut microbiota
fermentation of dietary fiber and serves as an important neuromodulator in the central …

Ischemic stroke is a disease with high morbidity and mortality worldwide, which often places
an additional strain on families and society due to the poor prognosis. Blood brain-barrier …

MicroRNAs (miRNAs) have been widely reported to induce posttranscriptional gene
silencing and led to an explosion of new strategies for the treatment of human disease. It has …

Background. Cerebral ischemic stroke (CIS) is a common cerebrovascular disease whose
main risks include necrosis, apoptosis, and cerebral infarction. But few therapeutic advances …

Abstract Hyperbaric oxygen therapy (HBOT), a technique through which 100% oxygen is
provided at a pressure higher than 1 atm absolute (ATA), has become a well-established …

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Background: Sirtuin1 is an epigenetic enzyme involved in histone and nonhistone protein
deacetylation. It acts primarily as a metabolic sensor, which responses to changing energy …

Diabetic patients are more vulnerable to cerebral ischemia-reperfusion (CIR) injury and
have a worse prognosis and higher mortality after ischemic stroke than non-diabetic …