Palmitic acid is a saturated fatty acid whose blood concentration is elevated in obese
patients. This causes inflammatory responses, where toll-like receptors (TLR), TLR2 and …

Malignant cells utilize diverse strategies that enable them to thrive under adverse conditions
while simultaneously inhibiting the development of anti-tumor immune responses. Hostile …

Many human diseases, including metabolic, immune and central nervous system disorders,
as well as cancer, are the consequence of an alteration in lipid metabolic enzymes and their …

Endoplasmic reticulum (ER) is a dynamic organelle that participates in a number of cellular
functions by controlling lipid metabolism, calcium stores, and proteostasis. Under stressful …

Phosphatidylethanolamine (PE) is the second most abundant phospholipid in mammalian
cells. PE comprises about 15–25% of the total lipid in mammalian cells; it is enriched in the …

Solid tumors typically develop hostile microenvironments characterized by irregular
vascularization and poor oxygen (O 2) and nutrient supply. Whereas normal cells modulate …

Excessive levels of saturated fatty acids are toxic to cells, although the basis for this
lipotoxicity remains incompletely understood. Here, we analyzed the transcriptome …

Resistance of cancer cells to chemotherapy is the first cause of cancer-associated death.
Thus, new strategies to deal with the evasion of drug response and to improve clinical …

Cellular membranes are composed of numerous kinds of glycerophospholipids with different
combinations of polar heads at the sn-3 position and acyl moieties at the sn-1 and sn-2 …

Immune responses occur in the midst of a variety of cellular stresses that can severely
perturb endoplasmic reticulum (ER) function. The unfolded protein response is a three …