Glaucoma and biomechanics
Biomechanics remains an active aspect of glaucoma research, with activity in both basic
science and clinical translation. However, the role of biomechanics in glaucoma remains …
science and clinical translation. However, the role of biomechanics in glaucoma remains …
Trabecular meshwork movement controls distal valves and Chambers: new glaucoma medical and surgical targets
M Johnstone, C Xin, E Martin, R Wang - Journal of Clinical Medicine, 2023 - mdpi.com
Herein, we provide evidence that human regulation of aqueous outflow is by a pump-conduit
system similar to that of the lymphatics. Direct observation documents pulsatile aqueous flow …
system similar to that of the lymphatics. Direct observation documents pulsatile aqueous flow …
Morphological and biomechanical analyses of the human healthy and glaucomatous aqueous outflow pathway: imaging-to-modeling
Abstract Background and Objective: Intraocular pressure (IOP) is maintained via a dynamic
balance between the production of aqueous humor and its drainage through the trabecular …
balance between the production of aqueous humor and its drainage through the trabecular …
Viscoelastic biomechanical properties of the conventional aqueous outflow pathway tissues in healthy and glaucoma human eyes
Background: Although the tissues comprising the ocular conventional outflow pathway have
shown strong viscoelastic mechanical response to aqueous humor pressure dynamics, the …
shown strong viscoelastic mechanical response to aqueous humor pressure dynamics, the …
Developing an experimental-computational workflow to study the biomechanics of the human conventional aqueous outflow pathway
The aqueous humor actively interacts with the trabecular meshwork (TM), juxtacanalicular
tissue (JCT), and Schlemm's canal (SC) through a dynamic fluid-structure interaction (FSI) …
tissue (JCT), and Schlemm's canal (SC) through a dynamic fluid-structure interaction (FSI) …
Biomechanics of human trabecular meshwork in healthy and glaucoma eyes via dynamic Schlemm's canal pressurization
Background and objective The trabecular meshwork (TM) consists of extracellular matrix
(ECM) with embedded collagen and elastin fibers providing its mechanical support. TM …
(ECM) with embedded collagen and elastin fibers providing its mechanical support. TM …
Rare protective variants and glaucoma-relevant cell stressors modulate Angiopoietin-like 7 expression
IF Aboobakar, ERA Collantes… - Human Molecular …, 2023 - academic.oup.com
Rare missense and nonsense variants in the Angiopoietin-like 7 (ANGPTL7) gene confer
protection from primary open-angle glaucoma (POAG), though the functional mechanism …
protection from primary open-angle glaucoma (POAG), though the functional mechanism …
Multiomics analysis reveals the mechanical stress-dependent changes in trabecular meshwork cytoskeletal-extracellular matrix interactions
A Soundararajan, T Wang, R Sundararajan… - Frontiers in cell and …, 2022 - frontiersin.org
Trabecular meshwork (TM) tissue is subjected to constant mechanical stress due to the
ocular pulse created by the cardiac cycle. This brings about alterations in the membrane …
ocular pulse created by the cardiac cycle. This brings about alterations in the membrane …
Segmental biomechanics of the normal and glaucomatous human aqueous outflow pathway
The conventional aqueous outflow pathway, encompassing the trabecular meshwork (TM),
juxtacanalicular connective tissue (JCT), and inner wall endothelium of Schlemm's canal …
juxtacanalicular connective tissue (JCT), and inner wall endothelium of Schlemm's canal …
Acoustic radiation force optical coherence elastography: A preliminary study on biomechanical properties of trabecular meshwork
S Ai, Y Zhang, G Shi, Y Wang, G Liu… - Journal of …, 2023 - Wiley Online Library
Evaluating biomechanical properties of trabecular meshwork (TM) is of great significance for
understanding the mechanism of aqueous humor circulation and its relationship to some …
understanding the mechanism of aqueous humor circulation and its relationship to some …