Designing clinical trials to address alcohol use and alcohol-associated liver disease: an expert panel Consensus Statement

BP Lee, K Witkiewitz, J Mellinger, FA Anania… - Nature Reviews …, 2024 - nature.com
Most patients with alcohol-associated liver disease (ALD) engage in heavy drinking defined
as 4 or more drinks per day (56 g) or 8 (112 g) or more drinks per week for women and 5 or …

Immunological mechanisms in steatotic liver diseases: An overview and clinical perspectives

M Yan, S Man, L Ma, L Guo, L Huang… - Clinical and Molecular …, 2024 - e-cmh.org
Steatotic liver diseases (SLD) are the principal worldwide cause of cirrhosis and end-stage
liver cancer, affecting nearly a quarter of the global population. SLD includes metabolic …

Inflammation in alcohol-associated hepatitis: pathogenesis and therapeutic targets

D Feng, S Hwang, A Guillot, Y Wang, Y Guan… - Cellular and Molecular …, 2024 - Elsevier
Alcohol-associated hepatitis (AH) is an acute-on-chronic liver injury that occurs in patients
with chronic alcohol-associated liver disease (ALD). Patients with severe AH have high short …

Research Priorities and Future Landscape of Clinical Trials in Alcohol-Associated Liver Disease

AV Kulkarni, AK Singal, PS Kamath - Clinics in Liver Disease, 2024 - liver.theclinics.com
Research Priorities and Future Landscape of Clinical Trials in Alcohol-Associated Liver
Disease - Clinics in Liver Disease Skip to Main Content Skip to Main Menu Advertisement …

Current Medical Treatment of Alcohol-Associated Liver Disease: Nutrition and Pharmacologic

JE Hardesty, CJ McClain - Clinics in Liver Disease, 2024 - liver.theclinics.com
Alcohol-associated liver disease (ALD) spans a spectrum of severity ranging from simple
steatosis to steatohepatitis to cirrhosis and potentially to hepatocellular carcinoma. Therapy …

Expedited liver transplantation as first‐line therapy for severe alcohol hepatitis: ELFSAH; deferring corticosteroids in the sickest subset of patients

N Mohy‐ud‐din, FP Lin, V Rachakonda… - Clinical …, 2024 - Wiley Online Library
Background & aims Severe alcohol‐associated hepatitis (SAH) represents a lethal subset of
alcohol‐associated liver disease. Although corticosteroids are recommended by guidelines …

Alcohol-Associated liver disease: Emerging therapeutic strategies

BH Mullish, MR Thursz - Hepatology - journals.lww.com
The large and growing burden of alcohol-related liver disease (ALD)–and the considerable
burden of morbidity and mortality associated with it–has been a drive towards ongoing …

Acute kidney injury in severe alcohol-associated hepatitis treated with anakinra plus zinc or prednisone

KR Patidar, W Tu, TG Cotter, DA Simonetto… - Hepatology - journals.lww.com
Acute Kidney Injury in Severe Alcohol-Associated Hepatitis Treated with Anakinra plus Zinc or
Prednisone Kavish R. Patidar1,2, W Page 1 Acute Kidney Injury in Severe Alcohol-Associated …

[引用][C] Association of myokines with disease progression and outcomes in patients with alcohol‐associated liver disease

J Lv, Y Ying, C Du - Alimentary Pharmacology & Therapeutics, 2024 - Wiley Online Library
Letter: Association of myokines with disease progression and outcomes in patients with
alcohol‐associated liver disease Page 1 Aliment Pharmacol Ther. 2024;00:1–2 …

[引用][C] Targeting IL-1 in severe alcohol-related hepatitis: How many frogs will we need to kiss to find an effective therapy?

M Thursz, P Mathurin - Journal of Hepatology, 2024 - journal-of-hepatology.eu
Alcohol-related hepatitis (AH) is an acute presentation of alcohol-related liver disease
characterised by jaundice and features of liver failure on a background of heavy and recent …