Cancer divergence has many facets other than being considered a genetic term. It is a
tremendous challenge to understand the metastasis and therapy response in cancer …

Despite considerable amount of research, the poor prognosis of patients diagnosed with
glioblastoma multiforme (GBM) critically needs new drug development to improve clinical …

Objective: To investigate the local immune status and its prognostic value in glioma.
Methods: A cohort of 297 glioma samples with whole genome microarray expression data …

Glioblastoma (GBM) is the most prevalent primary brain tumor and ranks among the most
lethal of human cancers with conventional therapy offering only palliation. Great strides have …

Background In humans, interferon-α treatment for chronic viral hepatitis is a well-recognized
clinical model for inflammation-induced depression, but the molecular mechanisms …

During the past decade, incorporating anti-angiogenic agents into the therapeutic
management of a myriad of malignancies has in certain cases made a significant impact on …

There are few tumor cell subpopulations with stem cell characteristics in tumor tissue,
defined as cancer stem cells (CSCs) or cancer stem-like cells (CSLCs), which can …

Cancer stem cells (CSCs), which have a close connection with tumor microenvironment,
play a pivotal role in tumorigenesis, tumor progression, and metastasis. The inflammatory …

Natural compounds originating from plants offer a wide range of pharmacological potential
and have traditionally been used to treat a wide range of diseases including cancer …

Glioblastomas (GBMs) are the most prevalent and devastating primary intracranial
malignancies and have extensive heterogeneity. Notch1 signaling is a more complex …