The pancreatic islet β cell senses circulating levels of calorigenic nutrients to secrete insulin
according to the needs of the organism. Altered insulin secretion is linked to various …

Elevated plasma glucose leads to pancreatic β cell dysfunction and death in type 2 diabetes.
Glycogen accumulation, due to impaired metabolism, contributes to this" glucotoxicity" via …

Postnatal maintenance or regeneration of pancreatic beta cells is considered to occur
exclusively via the replication of existing beta cells, but clinically meaningful restoration of …

Objective Dedifferentiation of pancreatic β-cells may reduce islet function in type 2 diabetes
(T2D). However, the prevalence, plasticity and functional consequences of this cellular state …

Transcriptionally mature and immature β-cells co-exist within the adult islet. How such
diversity contributes to insulin release remains poorly understood. Here we show that subtle …

Using an integrated approach to characterize the pancreatic tissue and isolated islets from a
33-year-old with 17 years of type 1 diabetes (T1D), we found that donor islets contained β …

Genome wide association studies (GWAS) for fasting glucose (FG) and insulin (FI) have
identified common variant signals which explain 4.8% and 1.2% of trait variance …

The identification of genes associated with human pancreatic beta cell maturation could
stimulate a better understanding of normal human islet development and function, be …

Background Weight loss can improve the metabolic complications of obesity. However, it is
unclear whether insulin resistance persists despite weight loss and whether any protective …

Cathelicidin antimicrobial peptide (CAMP) is a naturally occurring secreted peptide that is
expressed in several organs with pleiotropic roles in immunomodulation, wound healing …