Chagas disease (CD) is a centenarian neglected parasitosis caused by the protozoan
Trypanosoma cruzi (T. cruzi). Despite the continuous efforts of many organizations and …

In the past two decades, drug candidates with a covalent binding mode have gained the
interest of medicinal chemists, as several covalent anticancer drugs have successfully …

Abstract Chagas disease and Human African Trypanosomiasis (HAT) are caused by
Trypanosoma cruzi and T. brucei parasites, respectively. Cruzain (CRZ) and Rhodesain …

Gallinamide A, a metabolite of the marine cyanobacterium Schizothrix sp., selectively
inhibits cathepsin L-like cysteine proteases. We evaluated the potency of gallinamide A and …

Chagas disease is caused by the eukaryote parasite Trypanosoma cruzi. Current treatment
exhibits limited efficacy and selenium-based compounds emerged as promising candidates …

The protozoa, Trypanosoma cruzi (etiological agent of Chagas diseases–also named
American trypanosomiasis) and T. brucei (causative agent of human African …

Some copper (II) and zinc (II) complexes with oxindolimine ligands were tested regarding
their trypanocidal properties. These complexes have already shown good biological activity …

Trypanosoma cruzi (T. cruzi) and Trypanosoma brucei (T. brucei) urgently demand
innovative drug development due to their impact on public health worldwide. Their cysteine …

Chagas disease, after more than a century after its discovery, is still a major public health
problem. It is estimated that approximately 10 million people worldwide are infected with T …

Trypanosoma cruzi, a flagellate protozoan parasite, is responsible for Chagas disease. The
parasite major cysteine protease, cruzain (Cz), plays a vital role at every stage of its life cycle …