Schistosomiasis vaccine development: update on human clinical trials

AJ Molehin - Journal of biomedical science, 2020 - Springer
Schistosomiasis causes significant levels of morbidity and mortality in many geographical
regions of the world. The disease is caused by infections with parasitic blood flukes known …

[HTML][HTML] Circulating Anodic Antigen (CAA): a highly sensitive diagnostic biomarker to detect active Schistosoma infections—improvement and use during SCORE

PLAM Corstjens, CJ de Dood, S Knopp… - The American journal …, 2020 - ncbi.nlm.nih.gov
The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) was
funded in 2008 to conduct research that would support country schistosomiasis control …

A controlled human Schistosoma mansoni infection model to advance novel drugs, vaccines and diagnostics

MCC Langenberg, MA Hoogerwerf, JPR Koopman… - Nature medicine, 2020 - nature.com
Schistosomiasis treatment relies on the use of a single drug, praziquantel, which is
insufficient to control transmission in highly endemic areas. Novel medicines and vaccines …

A critical review on human malaria and schistosomiasis vaccines: current state, recent advancements, and developments

AJ Siddiqui, J Bhardwaj, J Saxena, S Jahan, M Snoussi… - Vaccines, 2023 - mdpi.com
Malaria and schistosomiasis are two major parasitic diseases that remain leading causes of
morbidity and mortality worldwide. Co-infections of these two parasites are common in the …

Schistosomiasis and hookworm infection in humans: Disease burden, pathobiology and anthelmintic vaccines

N Tsuji - Parasitology international, 2020 - Elsevier
Helminth diseases are the ancient scourges of humans and their damages are 'silent and
insidious'. Of the helminth infections, schistosomiasis and hookworm infection have a great …

Context-specific procedures for the diagnosis of human schistosomiasis–a mini review

PT Hoekstra, GJ van Dam… - Frontiers in Tropical …, 2021 - frontiersin.org
Schistosomiasis is a parasitic disease caused by trematode blood flukes of the genus
Schistosoma, affecting over 250 million people mainly in the tropics. Clinically, the disease …

Advancing the development of a human schistosomiasis vaccine

PJ Hotez, ME Bottazzi, J Bethony, DD Diemert - Trends in parasitology, 2019 - cell.com
Three vaccines against human schistosomiasis are in different phases of clinical
development, and a fourth is expected to enter the clinic soon. Successful introduction of an …

Immunological Considerations for Schistosoma Vaccine Development: Transitioning to Endemic Settings

E Driciru, JPR Koopman, S Cose, AA Siddiqui… - Frontiers in …, 2021 - frontiersin.org
Despite mass drug administration programmes with praziquantel, the prevalence of
schistosomiasis remains high. A vaccine is urgently needed to control transmission of this …

Sm‐p80‐based schistosomiasis vaccine: double‐blind preclinical trial in baboons demonstrates comprehensive prophylactic and parasite transmission‐blocking …

W Zhang, AJ Molehin, JU Rojo… - Annals of the New …, 2018 - Wiley Online Library
Schistosomiasis is of public health importance to an estimated one billion people in 79
countries. A vaccine is urgently needed. Here, we report the results of four independent …

[HTML][HTML] Immune responses in liver and spleen against Plasmodium yoelii pre-erythrocytic stages in Swiss mice model

AJ Siddiqui, J Bhardwaj, M Goyal, K Prakash… - Journal of Advanced …, 2020 - Elsevier
Though the immunity to malaria has been associated with cellular immune responses, the
exact function of the phenotypic cell population is still unclear. This study investigated the …