Schistosomiasis vaccine development: update on human clinical trials
AJ Molehin - Journal of biomedical science, 2020 - Springer
Schistosomiasis causes significant levels of morbidity and mortality in many geographical
regions of the world. The disease is caused by infections with parasitic blood flukes known …
regions of the world. The disease is caused by infections with parasitic blood flukes known …
[HTML][HTML] Circulating Anodic Antigen (CAA): a highly sensitive diagnostic biomarker to detect active Schistosoma infections—improvement and use during SCORE
PLAM Corstjens, CJ de Dood, S Knopp… - The American journal …, 2020 - ncbi.nlm.nih.gov
The Schistosomiasis Consortium for Operational Research and Evaluation (SCORE) was
funded in 2008 to conduct research that would support country schistosomiasis control …
funded in 2008 to conduct research that would support country schistosomiasis control …
A controlled human Schistosoma mansoni infection model to advance novel drugs, vaccines and diagnostics
MCC Langenberg, MA Hoogerwerf, JPR Koopman… - Nature medicine, 2020 - nature.com
Schistosomiasis treatment relies on the use of a single drug, praziquantel, which is
insufficient to control transmission in highly endemic areas. Novel medicines and vaccines …
insufficient to control transmission in highly endemic areas. Novel medicines and vaccines …
A critical review on human malaria and schistosomiasis vaccines: current state, recent advancements, and developments
Malaria and schistosomiasis are two major parasitic diseases that remain leading causes of
morbidity and mortality worldwide. Co-infections of these two parasites are common in the …
morbidity and mortality worldwide. Co-infections of these two parasites are common in the …
Schistosomiasis and hookworm infection in humans: Disease burden, pathobiology and anthelmintic vaccines
N Tsuji - Parasitology international, 2020 - Elsevier
Helminth diseases are the ancient scourges of humans and their damages are 'silent and
insidious'. Of the helminth infections, schistosomiasis and hookworm infection have a great …
insidious'. Of the helminth infections, schistosomiasis and hookworm infection have a great …
Context-specific procedures for the diagnosis of human schistosomiasis–a mini review
PT Hoekstra, GJ van Dam… - Frontiers in Tropical …, 2021 - frontiersin.org
Schistosomiasis is a parasitic disease caused by trematode blood flukes of the genus
Schistosoma, affecting over 250 million people mainly in the tropics. Clinically, the disease …
Schistosoma, affecting over 250 million people mainly in the tropics. Clinically, the disease …
Advancing the development of a human schistosomiasis vaccine
Three vaccines against human schistosomiasis are in different phases of clinical
development, and a fourth is expected to enter the clinic soon. Successful introduction of an …
development, and a fourth is expected to enter the clinic soon. Successful introduction of an …
Immunological Considerations for Schistosoma Vaccine Development: Transitioning to Endemic Settings
E Driciru, JPR Koopman, S Cose, AA Siddiqui… - Frontiers in …, 2021 - frontiersin.org
Despite mass drug administration programmes with praziquantel, the prevalence of
schistosomiasis remains high. A vaccine is urgently needed to control transmission of this …
schistosomiasis remains high. A vaccine is urgently needed to control transmission of this …
Sm‐p80‐based schistosomiasis vaccine: double‐blind preclinical trial in baboons demonstrates comprehensive prophylactic and parasite transmission‐blocking …
W Zhang, AJ Molehin, JU Rojo… - Annals of the New …, 2018 - Wiley Online Library
Schistosomiasis is of public health importance to an estimated one billion people in 79
countries. A vaccine is urgently needed. Here, we report the results of four independent …
countries. A vaccine is urgently needed. Here, we report the results of four independent …
[HTML][HTML] Immune responses in liver and spleen against Plasmodium yoelii pre-erythrocytic stages in Swiss mice model
Though the immunity to malaria has been associated with cellular immune responses, the
exact function of the phenotypic cell population is still unclear. This study investigated the …
exact function of the phenotypic cell population is still unclear. This study investigated the …