Multiple factors combined are currently recognized as contributors to cognitive decline. The
main independent risk factor for cognitive impairment and dementia is advanced age …

The strategies involved in the development of therapeutics for neurodegenerative disorders
are very complex and challenging due to the existence of the blood-brain barrier (BBB), a …

Alzheimer disease (AD) accounts for 60–70% of dementia cases. Given the seriousness of
the disease and continual increase in patient numbers, developing effective therapies to …

Alzheimer's disease (AD) is the most common progressive human neurodegenerative
disorder affecting elderly population worldwide. Hence, prevention of AD has been a priority …

The term vascular cognitive impairment (VCI) was introduced around the start of the new
millennium and refers to the contribution of vascular pathology to any severity of cognitive …

Background—Alzheimer's disease (AD) is a multifactorial, progressive, neurodegenerative
disease that is characterized by memory loss, personality changes, and a decline in …

Stroke is a leading cause of death and disability worldwide, and approximately 87% of
cases are attributed to ischemia. The main factors that cause ischemic stroke include …

The incidence and mortality of strokes have increased over the past three decades in China.
Ischemic strokes can cause a sequence of detrimental events in patients, including …

The function of the brain-derived neurotrophic factor (BDNF) via activation through its high-
affinity receptor Tropomyosin receptor kinase B (TrkB) has a pivotal role in cell …

Nicotinamide phosphoribosyltransferase (NAMPT) maintains mitochondrial function and
protects against cerebral ischemic injury by improving energy metabolism. Notoginsenoside …