Disturbances in the glutamatergic system have been increasingly documented in several
neuropsychiatric disorders, including autism spectrum disorder (ASD). Glutamate-centered …

The monoamine model of depression has long formed the basis of drug development but
fails to explain treatment resistance or associations with stress or inflammation. Recent …

The excitatory‐inhibitory imbalance hypothesis postulates dysregulation of the gamma‐
aminobutyric acid (GABA) and glutamate (Glu) neurotransmitter systems as a common …

Recent advances in genomics have revealed a wide spectrum of genetic variants
associated with neurodevelopmental disorders at an unprecedented scale. An increasing …

More than 100 single gene mutations and copy number variants convey risk for autism
spectrum disorder. To understand the extent to which each mutation contributes to the …

Background Individuals on the autism spectrum have been long described to process
sensory information differently than neurotypical individuals. While much effort has been …

Abstract Background According to Bayesian hypotheses, individuals with Autism Spectrum
Disorder (ASD) have difficulties making accurate predictions about their environment. In …

Real-time tracking of neurotransmitter levels in vivo has been technically challenging due to
the low spatiotemporal resolution of current methods. Since the imbalance of cortical …

Autism Spectrum Disorder (ASD) is a progressive neurodevelopmental disorder mainly
characterized by deficits in social communication and stereotyped behaviors and interests …

Altered reactivity and responses to auditory input are core to the diagnosis of autism
spectrum disorder (ASD). Preclinical models implicate ϒ-aminobutyric acid (GABA) in this …