Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …

In high-, middle-and low-income countries, the rising prevalence of obesity is the underlying
cause of numerous health complications and increased mortality. Being a complex and …

Candidate gene and genome-wide association studies have led to the discovery of nine loci
involved in Mendelian forms of obesity and 58 loci contributing to polygenic obesity. These …

Context Second-generation antipsychotics (SGAs) are increasingly used in the treatment of
many psychotic and nonpsychotic disorders. Unfortunately, SGAs are often associated with …

Background Genome-wide association studies on Europeans have shown that two
polymorphisms (rs17782313, rs12970134) near the melanocortin 4 receptor (MC4R) gene …

The melanocortin-4 receptor gene (MC4R) has intensively been analyzed in molecular
genetic obesity research. Decreased MC4R activity leads to obesity. Currently 166 …

Introduction: Childhood obesity is occurring at alarming rates in both developed and
developing countries.“Obesogenic” environmental factors must be associated with variants …

Null mutations in the PCSK1 gene, encoding the proprotein convertase 1/3 (PC1/3), cause
recessive monogenic early onset obesity. Frequent coding variants that modestly impair …

In sheep, coat colour (and pattern) is one of the important traits of great biological, economic
and social importance. However, the genetics of sheep coat colour has not yet been fully …

Abstract Knowledge of epigenetically regulated biomarkers linked to obesity development is
still scarce. Improving molecular understanding of the involved factors and pathways would …